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Lunni Zhou on Muck Rack

Lunni Zhou

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Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility - Nature Communications

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By Qi Liu, Xiaochen Liang, Pengyu Chen, Shuo Yang, Yuqi Liu, Haibo Zhao, Jin Hu, Shan Feng, Shanshan Xie, Jianping Wu, Miao Gui, Lunni Zhou
| Nature Verified
Abstract Doublet microtubule (DMT)-associated proteins assemble and drive sperm flagella, which are essential for successful fertilization. However, the exact roles of different DMT-associated proteins in sperm function and the underlying molecular mechanisms remain elusive. Here, we generate four gene-knockout mice based on high-resolution structures targeting distinct DMT components: two intermediate filament-like tektins (TEKT1, TEKT5) and two enzymes (TSSK6, DUSP21).
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