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Miao Gui

As seen in: Nature, MDPI, Cell Press
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Articles

RGS22 is a metazoa-specific radial spoke component required for coordinated ciliary beating

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By Jiajun Luo, Ye-Jun Peng, Wei Xu, Huiwen Cao, Wei Li, Jialei Dai, Zhipeng Shi, Yong Huei Wang, Xiao-Meng Li, Huijie Zhao, Miao Gui, Chao Yu, Xueliang Zhu, Qianting Zhang, Anxuan Fang, Haomang Xu
| Nature Verified
Abstract In metazoan epithelia, arrays of motile cilia beat in a tissue-wide coordinated manner to drive unidirectional fluid flow. Whether radial spokes (RSs), which mediate mechano-signal transduction between the central pair and axonemal dynein arms, acquire metazoa-specific subunit(s) in evolution to facilitate this function remains poorly known. Here we report that Gα-GTPase activating protein family member RGS22 is a metazoa-specific component of RS1/2 complexes.
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Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia

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By Ting Luo, Shuo Yang, Yuan Jiang, Mengzhe Guo, Feng Yang, Zhangqi Xu, Lei Wu, Weize Xu, Miao Gui, Tianhua Zhou, Shanshan Xie, Chunxiao Huo, Junhua Xia
| Nature Verified
Abstract Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by defective mucociliary clearance due to impaired motile cilia function. Outer dynein arm docking complex subunit 1 (ODAD1) encodes a structural component of the outer dynein arm docking complex (ODA-DC), which is crucial for effective ciliary beating. However, the full spectrum of ODAD1-associated pathogenesis remains incompletely defined.
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Doublet microtubule-associated tektins and enzymes differentially regulate sperm flagellar integrity and motility - Nature Communications

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By Qi Liu, Xiaochen Liang, Pengyu Chen, Shuo Yang, Yuqi Liu, Haibo Zhao, Jin Hu, Shan Feng, Shanshan Xie, Jianping Wu, Miao Gui, Lunni Zhou
| Nature Verified
Abstract Doublet microtubule (DMT)-associated proteins assemble and drive sperm flagella, which are essential for successful fertilization. However, the exact roles of different DMT-associated proteins in sperm function and the underlying molecular mechanisms remain elusive. Here, we generate four gene-knockout mice based on high-resolution structures targeting distinct DMT components: two intermediate filament-like tektins (TEKT1, TEKT5) and two enzymes (TSSK6, DUSP21).
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