Lunxi Liang on Muck Rack

Lunxi Liang

As seen in: Cell Press
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Articles

A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity

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By Lunxi Liang, Huanbin Wang, Hubing Shi, Zhaoli Li
| Cell Press Verified
Many cancer-related proteins are controlled by composite post-translational modifications (PTMs), but prevalent strategies only target one type of modification. Here we describe a designed peptide that controls two types of modifications of the p53 tumor suppressor, based on the discovery of a protein complex that suppresses p53 (suppresome).
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