Lutz Ackermann on Muck Rack

Lutz Ackermann

Göttingen
As seen in: Color Research & Application, Nature, Wiley, Wiley Online Library, ACS Publications, Die Zeit, Science Magazine, Royal Society of Chemistry, Cell Press, Cell Reports Physical Science and
catalysis, electrochemistry, peptides, computation, late-stage diversification, in 3d
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Articles

Enantio- and regioselective nickel/photoredox-catalyzed cross-electrophile coupling of benzylic aziridines with alkynyl bromides

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By Neus Martínez-Bosch, Nithik Chintalacheruvu, Edismauro Garcia Freitas-Filho, Hongyan Lan, Zhao-Dong Xu, Zhuangzhi Shi, Lutz Ackermann, Dingyi Wang
| Science Magazine Verified
Abstract Alkynes with a proximal stereogenic center are a key structural element of many bioactive compounds, chemical probes, and functional materials and serve as a valuable synthon in organic synthesis.
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Single-pot mechanochemically-enabled fluorine atom closed-loop economy using PFASs as fluorinating agents

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By hao long, Georgina Kirby, Lutz Ackermann
| Nature Verified
Abstract Per- and polyfluoroalkyl substances (PFASs), also known as “forever chemicals”, pose an increasing threat to the environment and human health. Despite recent advancements in PFASs destruction, the recycling processes for such molecules remain limited to methods using high-temperatures or strong reducing agents. Sustainable degradation methods for PFASs, along with the subsequent utilization or recycling of the resulting fluorides, are indeed highly beneficial.
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Mechanochemical ligand-controlled regiodivergent hydroarylation of alkenes via iron-catalyzed C−H activation - Nature Communications

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By Lutz Ackermann
| Nature Verified
Abstract The iron-catalyzed hydroarylation of alkenes with indoles is a sustainable, effective synthetic transformation towards the construction of functionalized indoles - crucial motifs for various bioactive molecules and drug candidates. However, such transformations have proven challenging for unactivated alkenes, and the requirement for (super)stoichiometric amounts of reactive Grignard reagents has limited broader applications.
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