Luying Zhao
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Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by unresolved inflammation, yet precise mechanisms linking immune metabolism to disease progression remain elusive. Here, we identified myeloid-expressed Mas, a G protein-coupled receptor, as a critical metabolic checkpoint in MASLD. Mas expression is elevated in hepatic myeloid cells from patients and diet-induced mouse models.
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway
Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway† Overdose of Acetaminophen (APAP) is a major contributor to acute liver injury (ALI), a complex pathological process with limited effective treatments. Emerging evidence links lipid peroxidation to APAP-induced ALI.
Influence Mechanism of Knowledge Network on Regional Innovation Capability Based on Hydrogen Energy Industry
E3S Web of Conferences 409, 05008 (2023) Influence Mechanism of Knowledge Network on Regional Innovation Capability Based on Hydrogen Energy Industry 1, 2, 3 and 1* 1 School of Business, Sichuan University, Chengdu 610065, People’s Republic of China 2 Business School, University of Mannheim, Mannheim, 68131, Germany 3 Zigong Waterless Port Investment Development Co., Ltd., Zigong, 643000, People’s Republic of China * e-mail: cathyworkshop@126.com Abstract As an important factor of innovation,...
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