Lylah Drummond-Clarke

Keywords PARP1 DNA replication single-strand gaps BRCA1 BRCA2 Okazaki fragment homologous recombination RAD51 gap protection gap repair Get full text access Log in, subscribe or purchase for full access. References 1. Hottiger, M.O. ∙ Hassa, P.O. ∙ Lüscher, B. ... Toward a unified nomenclature for mammalian ADP-ribosyltransferases Trends Biochem. Sci. 2010; 35:208-219 2. Amé, J.-C. ∙ Spenlehauer, C. ∙ de Murcia, G. de The PARP superfamily BioEssays. 2004; 26:882-893 3. Rack, J.G.M. ∙ Palazzo, L. ∙ Ahel, I.

Exquisite sensitivity to CldU in SSBR-defective human cells lacking XRCC1 or PARP activity The single-strand break repair (SSBR) protein XRCC1 is critical for survival of CHO (Chinese hamster ovary) cells in media containing the thymidine analogue CldU (Dillehay et al, 1984).