Lysian Huber on Muck Rack

Lysian Huber

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Articles

Characterization of KRAS G12C inhibitor olomorasib single-agent and combination with activity in KRAS G12C -mutant models

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By Xi Lin, Robert Van Horn, Jack Dempsey, Eva M. Goetz, Robert Evans, Andrew Farber, Matthew J. VandeKopple, Hong Gao, Wei Xu, Nicholas Brown, Michele Dowless, Nicholas Pulliam, David Barda, Serge Boulet, Andrew Capen, Mark A. Castanares, Jennifer Stephens, Megan Johnson Verified, Junpeng Xiao, Josh Ballard, Michael Chalmers, Jing L. Wang, Jörg Hendle, Anita Sarkar, Frances Tung, Joseph Ho, Logan Rodgers, Jordi Obach Benach, Lian Zhou, Bradley L Ackermann, Sean Buchanan, James Henry, Xueqian Gong, Shengbin Peng, Youyan Zhang, Chong Si, Wenyu Ming, Chungping Yu, Deqi Guo, Lysian Huber, Bonita Jones, Sarah Bogner, Carmen L. Curtis, John M. Strelow, Wayne P. Bocchinfuso, Melbert D. Saflor, Danalyn Manglicmot Lagutan, Tarun Gheyi, Margaret Kearins, Anton Joseph Frommelt, Denis McCann, Anke Klippel
| Nature Verified
Abstract The impact of first-generation covalent KRASG12C inhibitors has been reduced due to the development of drug resistance, tolerability and challenges combining with immunotherapy. We designed olomorasib, a next-generation GDP-binding KRASG12C inhibitor, for nanomolar potency as well as selectivity over wild-type inhibition.
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