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Keywords proteogenomics lung adenocarcinoma genomics mass spectrometry PTMs biomarkers smokers never-smokers CPTAC ICPC Introduction Lung adenocarcinomas (LUAD), the most prevalent subtype of non-small cell lung cancers (NSCLC), represent a significant global health challenge with marked geographical and epidemiological diversity in incidence and disease progression.1 Despite advances in targeted therapies and improved diagnostic techniques, LUAD continue to exhibit high mortality rates,2...
PDX and human tumor samples and cell lines All experiments with live mice were performed according to institutional and national regulations and approved by the Institutional Animal Care and Use Committee at Washington University in St.Louis, MO. Patient-derived xenograft (PDX) tumors from established basal (WHIM6) and luminal (WHIM20) breast cancer subtypes were raised subcutaneously in 8-week-old NOD. Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (Jackson Labs, Bar Harbor, ME)44,83.
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