Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Ma Sha
07.13.26 -- Integrated Strategies For Simplifying CHO Bioprocessing
Webinar: Enhancing AAV Manufacturing Yield Through a Promoter-Optimized Mini-Helper Plasmid Discover how Samsung Biologics is advancing AAV manufacturing with a promoter-optimized mini-helper plasmid platform designed to improve productivity and reduce costs. This webinar explores the plasmid design strategy, transfection optimization, and scalability from flask to bioreactor production.
Chimeric Antigen Receptor Plasmid Production By Escherichia Coli Fermentation Using The SciVario® Twin Bioprocess Control System
By Ying Yang, Ma Sha, and Jorge Escobar Advancing chimeric antigen receptor (CAR) cell therapy development demands precise, scalable bioprocess control from early research through clinical manufacturing. Integrating single-use bioreactor technology with flexible control systems helps streamline this transition, enabling consistent cell expansion while reducing contamination risk and operational complexity.
06.15.26 -- Immobilized Enzymes Promise Alternative To Cyanogen Bromide's Toxicity
Webinar: Breaking the CLD Bottleneck: Generate Stable High-Producing Clones in 14 Weeks Accelerating cell line development is critical as monoclonal antibody modalities grow more complex. In this webinar, Thermo Fisher Scientific explores how the Gibco™ CHOvantage™ GS CLD kit enables rapid generation of stable, high-producing CHO cell lines for mAbs, bispecific antibodies, and fusion proteins.
Chimeric Antigen Receptor Plasmid Production By Escherichia Coli Fermentation Using The SciVario® Twin Bioprocess Control System
By Ying Yang, Ma Sha, and Jorge Escobar Advancing chimeric antigen receptor (CAR) cell therapy development demands precise, scalable bioprocess control from early research through clinical manufacturing. Integrating single-use bioreactor technology with flexible control systems helps streamline this transition, enabling consistent cell expansion while reducing contamination risk and operational complexity.
Beginner's Guide To Mesenchymal Stem Cell Culture With The SciVario® Twin Bioprocess Control Station
By Min Tang-Schomer and Ma Sha, Eppendorf, Inc. Challenges in scaling up mesenchymal stem cell (MSC) production are largely due to the adherent nature of MSCs, which requires them to be cultured on a surface. Microcarriers offer a solution by enabling the transition from traditional 2D culture to 3D stirred-tank bioreactor systems. However, this transition requires a carefully controlled workflow to ensure successful cell growth and quality.
01.29.26 -- Advancing Off-The-Shelf CRISPR CAR-T Therapies With Rachel Haurwitz
BioPlan Associates is conducting its 23rd Annual Global Biopharmaceutical Manufacturing and Trends Analysis and needs your insights for the biopharma industry’s most comprehensive global benchmarking analysis! For over 20 years, BioPlan Associates has analyzed advances in bioprocessing, new technologies, and emerging trends, supported by global institutional and media partners.
China's installed wind power capacity tops world for 15 years Original
For 15 consecutive years, China has ranked first worldwide in installed wind power capacity, with wind power forming a cornerstone of its transition toward a cleaner and more sustainable development model.
Infrared cameras catch panda courtship in different seasons in NW China Original
A rare sighting - twice, in different seasons! Freshly compiled from 2025 infrared camera data, these key courtship moments of two different panda pairs were captured in the Gansu section of China's Giant Panda National Park. #Pandamania #WildPandas #panda #GiantPanda
China transforms barren lands into solar thermal powerhouses Original
An aerial drone photo taken on July 16, 2024 shows a solar thermal energy storage power station in Guazhou County, northwest China's Gansu Province. (Xinhua) LANZHOU, Dec. 19 (Xinhua) -- In the vast, barren Gobi desert of northwestern China, over 25,000 heliostats arranged in concentric circles span a total reflective area of 770,000 square meters, equivalent to 108 standard football fields.
A Beginner's Guide To Sf9 Culture In Stirred-Tank Bioreactors
By Marcus Deinstadt and Ma Sha Sf9 insect cells are a popular expression platform for recombinant proteins due to their suspension culture capabilities, high growth rate, and post-translational modification abilities. This application note provides a comprehensive guide to culturing Sf9 cells and producing recombinant proteins using the baculovirus expression vector system in stirred-tank bioreactors.
Beginner's Guide To Mesenchymal Stem Cell Culture With The SciVario® Twin Bioprocess Control Station
By Min Tang-Schomer and Ma Sha, Eppendorf, Inc. Challenges in scaling up mesenchymal stem cell (MSC) production are largely due to the adherent nature of MSCs, which requires them to be cultured on a surface. Microcarriers offer a solution by enabling the transition from traditional 2D culture to 3D stirred-tank bioreactor systems. However, this transition requires a carefully controlled workflow to ensure successful cell growth and quality.
09.22.25 -- CDMO Hunger Games And The State Of Biotech
Webinar: Expert Roundtable: Real-World Process Intensification Strategies for Smarter Biomanufacturing Discover how leading experts are using process intensification (PI) to cut costs, boost yield, and future-proof biopharma manufacturing. In this Sartorius webinar, gain practical insights on modernizing legacy facilities, implementing PI across upstream and downstream, and leveraging automation, digital tools, and modular upgrades.
Coffee meets cave dwellings: fusion spot draws tourists in Gansu Original
When coffee meets traditional Chinese cave dwellings, the result is a unique cultural fusion. In Dingxi City, northwest China's Gansu Province, a newly opened coffee space blending East and West has become a summer draw for tourists.■
A Beginner's Guide To Sf9 Culture In Stirred-Tank Bioreactors
By Marcus Deinstadt and Ma Sha Sf9 insect cells are a popular expression platform for recombinant proteins due to their suspension culture capabilities, high growth rate, and post-translational modification abilities. This application note provides a comprehensive guide to culturing Sf9 cells and producing recombinant proteins using the baculovirus expression vector system in stirred-tank bioreactors.
Embark on a fun trip to an ancient Zootopia in NW China! Original
Imagine being able to observe the dawn of humanity in 2025! Well, now you can at a paleozoological museum in Gansu, China. Discover fascinating facts about some thrilling fossils!■
3 North China leopards spotted in NW China's Gansu
Three wild North China leopards, a mother and her cubs, were recently spotted together in a nature reserve in northwest China's Gansu Province. #leopard
03.24.25 -- Host Cell DNA Impurities: A Unique Challenge For rAAV
The rapid advance of ADCs has tested the fine balance between speed to IND and process development that stands up to the rigors of scale-up and transfer. Explore the processes leading ADC developers are employing to mitigate manufacturing-scale risk, and how automation and artificial intelligence are beginning to inform their work. Join Bioprocess Online Live for this interactive discussion. Registration is free thanks to the support of Thermo Fisher Scientific.
GLOBALink | Indonesian student's journey to fulfill childhood dream about Chinese shadow puppetry
Indonesian student Ivan has been fascinated by Chinese shadow puppetry since childhood. He recently visited birthplace of Daoqing shadow plays, a branch of Chinese shadow puppetry, and experienced charm of this national intangible cultural heritage. #GLOBALink
Human Induced Pluripotent Stem Cell Aggregate Expansion In Stirred-Tank Bioreactors Using SciVario ® Twin Bioprocess Controller
Get more Cell & Gene insight with our FREE newsletter By Jorge L. Escobar Ivirico and Ma Sha The implementation of cell-based therapies is often challenged by limited cell availability and process scalability. Human Induced Pluripotent Stem Cell (hiPSC) are an attractive cell platform choice for developing and manufacturing off-the-shelf cell products, as they are amenable to gene modification and can be expanded limitlessly.
Human Induced Pluripotent Stem Cell Aggregate Expansion In Stirred-Tank Bioreactors Using SciVario ® Twin Bioprocess Controller
By Jorge L. Escobar Ivirico and Ma Sha The implementation of cell-based therapies is often challenged by limited cell availability and process scalability. Human Induced Pluripotent Stem Cell (hiPSC) are an attractive cell platform choice for developing and manufacturing off-the-shelf cell products, as they are amenable to gene modification and can be expanded limitlessly.
Rare footage captures wild giant pandas strolling in NW China Original
Rare footage of wild giant pandas going for a stroll was captured by an infrared camera in the Giant Panda National Park's Baishuijiang area in NW China's Gansu Province. Enjoy watching two pandas, one large and one small, putting their charmingly clumsy demeanor on full display.■
Police rescue woman attempting suicide in NW China's Lanzhou Original
Recently, police officers successfully rescued a woman sitting on a pedestrian bridge, attempting to commit suicide, in northwest China's Lanzhou. #policerescue #China
Earthquake death toll rises to 131 in China's Gansu, Qinghai
The 6.2-magnitude earthquake that jolted China's Gansu at midnight Monday has killed 131 people in Gansu and neighboring Qinghai Province, said local authorities.
Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
La Chine découvre un champ pétrolifère avec des réserves de plus de 100 millions de tonnes
Changqing Oilfield, une filiale de PetroChina, a découvert un champ pétrolifère à grande échelle et bien préservé avec des réserves géologiques de plus de 100 millions de tonnes à Huanxian, district de la province du Gansu, dans le nord-ouest de la Chine. Changqing Oilfield a découvert des réserves de pétrole prouvées de 50,24 millions de tonnes et des réserves estimées de 56,2 millions de tonnes dans la région, a déclaré Niu Xiaobing, directeur général adjoint de la société Changqing Oilfield.
E. coli Plasmid DNA Production Using The DASbox® Mini Bioreactor System
By Nina Schrand and Ma Sha, Eppendorf In recent years, the need for improved high-yield plasmid DNA production strategies has significantly increased due to its application in the field of messenger RNA (mRNA) vaccines and gene therapy.
A Beginner's Guide To CHO Culture: Bioprocess Modes – Batch, Fed-Batch, And Perfusion
By Amanda Suttle and Ma Sha, Eppendorf Inc. Recombinant protein manufacturing in Chinese Hamster Ovary (CHO) cells represents more than 70 % of the entire biopharmaceutical industry. Specifically, human monoclonal antibodies (hmAbs) in CHO cells play a major role in the therapeutic markets and have for decades.
High-Density Escherichia Coli Fed-Batch Fermentation Using The SciVario® Twin Bioreactor Control System
By Robert Glaser, Anne Niehus, and Ma Sha In upstream bioprocessing, the feed strategy is an important parameter to achieve high cell densities. Experts have conducted a study which optimized high-cell-density fed-batch fermentation of Escherichia coli (E. coli) using the SciVario twin bioreactor control system equipped with a 1 L glass bioreactor.
A Beginner's Guide To CHO Culture: Bioprocess Modes – Batch, Fed-Batch, And Perfusion
By Amanda Suttle and Ma Sha, Eppendorf Inc. Recombinant protein manufacturing in Chinese Hamster Ovary (CHO) cells represents more than 70 % of the entire biopharmaceutical industry. Specifically, human monoclonal antibodies (hmAbs) in CHO cells play a major role in the therapeutic markets and have for decades.
Vol 21, Open Access (2022) - Human IgG Fc Production Through Methanol-Free Pichia pastoris Fermentation
Human IgG Fc Production Through Methanol-Free Pichia pastoris Fermentation By Ying Yang, Knut Madden, and Ma Sha Volume 21, Open Access (November 2022) Nowadays, therapeutic monoclonal antibodies (mAbs) are predominantly produced with mammalian cell culture systems such as those using Chinese hamster ovary (CHO) cells.
E. coli Plasmid DNA Production Using The DASbox® Mini Bioreactor System
By Nina Schrand and Ma Sha, Eppendorf In recent years, the need for improved high-yield plasmid DNA production strategies has significantly increased due to its application in the field of messenger RNA (mRNA) vaccines and gene therapy.
HEK293 Suspension Cell Culture Using The BioFlo® 320 Bioprocess Controller With BioBLU® 3c Single-Use Bioreactors
By Jorge L. Escobar Ivirico and Ma Sha, Eppendorf, Inc. Developing innovative preventive solutions through new vaccine technologies or gene therapy platforms that respond to new diseases is an important challenge in present day biotechnology. To produce high-quality biotherapeutics, process development involves several demanding components including cost, cell line development, small scale exploration, effective scaling, and optimization of upstream/downstream processes.
From Shaker To Fermenter: Methanol-Free Pichia Pastoris Protein Production Workflow
By Ying Yang, Ma Sha, Bioprocess Applications Lab, Eppendorf, Inc. The yeast Pichia pastoris has become an important and convenient workhorse for genetically engineered protein production in the biotechnology industry. Currently, most P. pastoris promoters used for efficient expression of heterologous proteins are derived from genes in the methanol metabolism pathway.
Vero Cell-Based Vaccine Production: Cell lines, Media And Bioreactor Options
By Ma Sha The Vero cell line is one of the most satisfactory vaccine production hosts based on its infectability, stability and well-documented performance in quality and quantity of viral yield. It is one of the first cell lines that received FDA approval for vaccine use and is used throughout the world. Cell culture media technology has advanced drastically in recent years, and a number of serum free and protein free options are available through commercial suppliers.
Anaerobic Clostridium Beijerinckii Fermentation In Small- Scale Bioreactor Control Systems
By Ying Yang, Robert Glaser, Nina Schrand, and Ma Sha To demonstrate the feasibility of conducting anaerobic fermentation in Eppendorf small scale fermenters, we grew the obligate anaerobe Clostridium beijerinckii, a natural producer of butanol and isopropanol, in BioBLU® f Single-Use Vessels controlled by the DASbox® Mini Bioreactor and DASGIP® Parallel Bioreactor Systems.
How Scale Up Assist Using the BioFlo® 720 Bioreactor Control System Can Help Your Antibody Production Workflow
By Amanda Suttle, John Longsworth, and Ma Sha, Eppendorf, Inc., To scale upstream bioprocesses, an effective scale-up strategy is required to ensure the reproducibility of both cell culture growth and batch yields at large working volumes, ideally with little or no additional optimization. The Constant Power approach is a successful method for matching bioreactor yields at different scales.
Microalgae Culture Using The DASGIP® PBR4 Module For Illumination With An Eppendorf Bench-Scale Stirred-Tank Bioreactor
By Stacey S. Willard, James Jarvis, Jean-François Hamel, and Ma Sha The number of bioprocess applications for microalgae has increased in recent years, particularly in the field of biofuel production. The combination of an Eppendorf bench-scale stirred-tank bioreactor and the DASGIP LED Illumination System creates a bioreactor setup which is capable of supporting high density microalgal growth.
Stem Cell Exosome Production On The SciVario® Twin
By Jorge L. Escobar Ivirico and Ma Sha, Eppendorf, Inc., Exosomes derived from mesenchymal stem cells (MSC) are a new alternative to restore tissues and organs, avoiding the limitations associated with stem cell therapy. MSC-derived exosomes are involved in MSC’s paracrine functions related to cell-to-cell communications and tissue reconstruction, leading to cell self-renewal and differentiation.
PID Controlled Constant RQ Fermentation Of Pichia Pastoris In The DASbox® Mini Bioreactor System
By Nina Schrand, Malte Schneider, Ma Sha Compared to mammalian cell culture, Pichia pastoris displays a much faster growth and requires less expensive growth medium, making it ideal for protein production in bioreactors. For optimizing the production yield of a P. pastoris culture, one of the most important factors is the feeding strategy.
Stolen Velour - Day 'N' Nite (rmx), by Stolen Velour
If you like Stolen Velour, you may also like:
Improving Antibody Production Workflow Using The BioFlo 720 Bioreactor Control System
By Amanda Suttle, John Longsworth, and Ma Sha, Eppendorf, Inc., To scale upstream bioprocesses, an effective scale-up strategy is required to ensure the reproducibility of both cell culture growth and batch yields at large working volumes, ideally with little or no additional optimization. The Constant Power approach is a successful method for matching bioreactor yields at different scales.
Measuring Oxygen Transfer Rate (OTR) Of The Eppendorf Fermentation Vessels
By Ying Yang and Ma Sha, Applications lab, Eppendorf Bioprocess Center, This short protocol describes the procedure to measure the oxygen transfer rate (OTR) of the Eppendorf fermentation vessels, an important parameter of the vessel specifications. It is crucial to measure OTR under industry standard conditions with 1 vessel volume per minute (VVM) of air sparging only without oxygen enrichment, as the increase of VVM or oxygen sparging will significantly inflate OTR values.
01.30.21 -- What You Need To Know Before Investing In A Bioprocessing Space
What You Need To Know Before Investing In A Bioprocessing Space By William Dow, Bioprocess Sales Engineer and Ma Sha, Ph.D., Head of Bioprocess Application Labs, Eppendorf Selecting the bioreactor that is best for your process and the dedicated space you have available requires consideration of many important factors. Is Your Definition Of Quality Culture The Same As The FDA's?
08.19.20 -- The Next Chapter In Ansun Biopharma's Turnaround Story
Article | By Matthew Jones, Thermo Fisher Scientific It is critical the experts creating a drug product’s formulation are aware of any reactions that can occur between an API and a tablet’s excipients. Article | By Ma Sha, Ph.D., and William Dow, Eppendorf Selecting the bioreactor that is best for your process and the dedicated space you have available requires consideration of many important factors.
Microcarrier Spin Filter: Vero Perfusion Culture - BioProcess International
Figure 1: Vero cell expansion process Anchorage-dependent cells such as Vero cells are used widely as a platform for viral vaccine production. Perfusion bioprocesses enable a constant addition of nutrients and removal of byproducts while cells are in a bioreactor. That results in cell densities that are higher than those for conventional batch or fed-batch processes. In the study herein, Eppendorf researchers tested the suitability of a spin filter as a cell-retention device.
08.10.20 -- Arrowhead's Dr. Anzalone: Taking RNAi Beyond The Liver
By Kip Wolf, Tunnell Consulting, @KipWolf If you think deepfake security risks are purely science fiction, think again. Not only does the technology exist and the content is readily available to facilitate such activities, but incentives to carry them out are multiplied in the current economic, social, and political environment.
A Guide To Pichia Pastoris Fermentation In Single-Use Stirred-Tank Bioreactors
By Ying Yang, Nina Schrand, and Ma Sha Pichia pastoris is a methylotrophic yeast largely used for heterologous protein production in biotechnology. As an expression system, the main advantages of P. pastoris over E. coli are that the eukaryotic P. pastoris is capable of carrying out post-translational modifications, such as glycosylation, and meanwhile secreting the protein of interest. Compared to mammalian cell culture, P.
Parallel Fed-batch CHO Culture On SciVario Twin
By Amanda Suttle and Ma Sha, Eppendorf, Inc., We performed fed-batch cultures using BioBLU® 1c and 3c Single-Use Vessels controlled in parallel by the new SciVario® twin bioreactor control system. This method highlights the SciVario twin’s capabilities to run complex processes simultaneously using various sized vessels. The initial release of SciVario twin can control vessel sizes from 0.7 L to 4 L.
Dissolved Oxygen Control PID Tuning For Cell Culture Applications
By John Longsworth, Nina Schillings, and Ma Sha Eppendorf bioprocess controllers, such as the BioFlo® 320 Bioreactor Control System, use a proportional– integral–derivative (PID) control mechanism for a variety of processes, including dissolved oxygen (DO) control. The PID control loop mechanism for DO control is essential for optimal bioreactor cell culture. Although the D value is not user adjustable in Eppendorf controllers, the P and I values can be changed.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Ma
Contact Ma, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack