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Maansi V. Gupta on Muck Rack

Maansi V. Gupta

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Discovery of a small molecule TLR3 agonist adjuvant - Nature Communications

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By Danica Dong, John Awad, Soumik Barman, Byron Brook, Manisha Menon, Timothy R. O’Meara, Sanya J. Thomas, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, Maansi V. Gupta
| Nature Verified
Abstract Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,000 small molecules for maturation of human monocytic cells by quantifying NF-κB activation and cell adherence was completed.
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