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Machel Leuschner

As seen in: MDPI
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Articles

Bioanalysis of the Geneva Phenotyping Cocktail in Whole Blood Collected with Volumetric Absorptive Microsampling by LC-MS/MS for Application in a South African Cohort

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By Machel Leuschner, Allan Duncan Cromarty, Kim Sheva
| Preprints.org
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 11 June 2024 / Approved: 11 June 2024 / Online: 11 June 2024 (18:26:02 CEST) Leuschner, M.; Cromarty, A. D.; Sheva, K. Bioanalysis of the Geneva Phenotyping Cocktail in Whole Blood Collected with Volumetric Absorptive Microsampling by LC-MS/MS for Application in a South African Cohort. Preprints 2024, 2024060728. https://doi.org/10.20944/preprints202406.0728.v1 Leuschner, M.; Cromarty, A. D.; Sheva, K.
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Critical Assessment of Phenotyping Cocktails for Clinical Use in an African Context

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By Machel Leuschner, Allan Duncan Cromarty, Allan Duncan
| MDPI
Abstract : Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent metabolism and altered drug absorption via expressed transport channels such as P-glycoprotein (P-gp) contribute to the adverse drug reactions, drug–drug interaction and therapeutic failure seen in clinical practice.
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