Cardiovascular disease (CVD) remains one of the largest global health challenges, and despite decades of progress in prevention, low-density lipoprotein cholesterol (LDL-C) continues to be a key driver of risk (). Statins have long been the cornerstone of treatment, but many patients, especially those at very high risk or who cannot tolerate statins. Need additional options (, ). That need has brought us in a new era of lipid-lowering therapies (LLTs), which is the focus of this Research Topic.