Mack Reynolds

Abstract Mitophagy is a selective autophagic process that eliminates damaged mitochondria via lysosomal degradation, playing a crucial role in maintaining cellular metabolic balance. Mitophagy can occur through two pathways: ubiquitin-dependent and ubiquitin-independent. Recently, we and others have shown that, upon mitochondrial stress, AMP-activated protein kinase (AMPK) contributes to Parkin-mediated, ubiquitin-dependent mitophagy.

💡 newsR Knowledge: Other News Mentions Tripura State in northeastern India Over the past 24 hours, relentless monsoon rains have devastated Northeast India, leading to catastrophic flooding and landslides that have claimed at least 22 lives across multiple states.

Keywords IRE1α innate immunity Candida albicans fungal infection phagosome calcium Research topic(s) CP: Immunology CP: Microbiology Introduction Intracellular infection by pathogens triggers cell stress programs, including the unfolded protein response (UPR), whose three branches (inositol-requiring enzyme 1α [IRE1α], protein kinase RNA-like endoplasmic reticulum kinase, and activating transcription factor 6 [ATF6]) have broad consequences for host defenses through the regulation of innate...