Maël Silva Rodriguez

Circulating Methylated SEPT9 for Detection of Hepatocellular Carcinoma in Cirrhosis Supplement 1. eTable 1. Extended Baseline Characteristics of Study Participants eTable 2. Outcome Definitions and Patient Distribution eTable 3. Baseline Characteristics of Study Participants According to Hepatocellular Carcinoma Status at Enrollment eTable 4. Comparison of Baseline Characteristics Between Included and Excluded Participants eTable 5.

ACMG American College of Medical Genetics and Genomics ALT alanine aminotransferase AST aspartate aminotransferase CES clinical exome sequencing ERYTHRO-HEME erythropoiesis and heme biosynthesis GGT gamma-glutamyltransferase HEPATO-METAB hepatic metabolism and lysosomal storage HGVS Human Genome Variation Society HIC hepatic iron concentration HMZ homozygous HTZ heterozygous IQR interquartile range IRON-SENS systemic iron sensing and hepcidin regulation IRON-TRANS iron transport and storage...

1 Introduction Metabolic and genetic disorders may closely mimic clinical and morphological features of myelodysplastic syndromes (MDS). Cases with combined B12/folate deficiencies can appear as clonal disorders, particularly when neurological manifestations are present. 2 Case History/Examination A 39-year-old woman exhibited progressive paresthesias, ataxia, and pancytopenia. The patient was free of clinical physical abnormality and no family history of hematological diseases was recorded.