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Maëlle Lorvellec on Muck Rack

Maëlle Lorvellec

As seen in: Nature, Cell Press
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Articles

An In Vitro Whole-Organ Liver Engineering for Testing of Genetic Therapies

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By Maëlle Lorvellec, Alessandro Filippo Pellegata, Alice Maestri
| Cell Press Verified
Highlights • Generation of a perfused humanized in vitro whole liver bioreactor model: BALM • BALM improves maturation and long-term survival of human iPS-derived hepatocytes • BALM allows viral transduction of human iHEPs through its vasculature • BALM provides a tool for gene therapy testing of human iHEPs Summary Explosion of gene therapy approaches for treating rare monogenic and common liver disorders created an urgent need for disease models able to replicate human liver cellular...
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Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by <i>Asl</i> gene transfer

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By Julien Baruteau, Dany P. Perocheau, Joanna Hanley, Maëlle Lorvellec
| Nature Verified
The AslNeo/Neo mice (B6.129S7-Asltm1Brle/J) were purchased from Jackson Laboratory (Bar Harbor, ME). For the initial experiments studying the neurological phenotype, WT and AslNeo/Neo littermates were maintained on standard rodent chow (Harlan 2018, Teklab Diets, Madison, WI; protein content 18%) with free access to water.
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