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As seen in: Frontiers, Cell Reports
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Articles

Frontiers | Identification of genetic variants associated with a wide spectrum of phenotypes clinically diagnosed as Sanfilippo and Morquio syndromes using Whole Genome Sequencing

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By Maersk Tower, Anne C B
| Frontiers
Asmat Ullah1 Rutaba Gul1 Sabika Firasat2* Mikkel Schubert1 Elionora Peña3 Anne C. Thuesen3 Anette P.
Open in Who Shared Issue with article?

Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

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By Mette Trauelsen, Maersk Tower, Thomas K Hiron, Da Lin Verified
| Cell Reports Verified
Highlights • Succinate and CES but not large synthetic SUCNR1 agonists stimulate gene transcription • SUCNR1 activates transcriptional reporters through Gq and PLC and not Gi signaling • Extracellular succinate regulates immunological genes in M2 macrophages through SUCNR1 • SUCNR1 signaling through Gq hyperpolarizes human M2 macrophages Summary Succinate functions both as a classical TCA cycle metabolite and an extracellular metabolic stress signal sensed by the mainly Gi-coupled succinate...
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