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Magdalini Serefidou on Muck Rack

Magdalini Serefidou

As seen in: Cell Press
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Articles

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

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By Ludwig-Maximilians-, Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou
| Cell Press Verified
Highlights • Macrophages adopt a transient metabolic state in response to TLR4 activation • MyD88 and TRIF synergistically facilitate signaling-driven changes in metabolism • Increases in glycolysis and ATP-citrate lyase activity foster histone acetylation • ATP-citrate lyase governs gene induction of a distinct LPS responsive gene set Summary Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by activating temporally defined transcriptional cascades.
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