Mahantesh Biradar

Abstract GWAS of primary angle-closure glaucoma have identified eight loci conferring risk in Asian populations. However, it remains unclear whether the genetic risk factors for the disease are consistent across different populations. Here, we present a discovery GWAS for primary angle-closure glaucoma in Europeans using the UK Biobank. We replicate our findings in six independent European populations and compare these results with results from 14 Asian cohorts.

Keywords GWAS AI multimodal deep learning PRS cardiovascular disease representation learning fusion model variational autoencoder Introduction Health data (e.g., electrocardiograms [ECGs], photoplethysmograms [PPGs], spirograms, magnetic resonance imaging [MRI]) are valuable assets for clinical diagnosis, treatment, and prognosis and provide a unique opportunity for studying the genetic basis of complex traits.1,2,3,4,5,6,7,8,9 Recent technological progress in electronic health record (EHR)...

Y.Z., J.C., T.Y., Z.R.M., J.B., H.Y., A.C., C.Y.M., B.B., and F.H. are current or former employees of Google, and own Alphabet stock as part of the standard compensation package. Y.Z., J.C., T.Y., Z.R.M., J.B., H.Y., A.C., C.Y.M., B.B., and F.H. are current or former employees of Google and received salary, bonus, and stock awards as part of the standard compensation package.