Articles by Mahantesh Biradar
GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology - Nature Communications
Abstract GWAS of primary angle-closure glaucoma have identified eight loci conferring risk in Asian populations. However, it remains unclear whether the genetic risk factors for the disease are consistent across different populations. Here, we present a discovery GWAS for primary angle-closure glaucoma in Europeans using the UK Biobank. We replicate our findings in six independent European populations and compare these results with results from 14 Asian cohorts.
Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits
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Keywords GWAS AI multimodal deep learning PRS cardiovascular disease representation learning fusion model variational autoencoder Introduction Health data (e.g., electrocardiograms [ECGs], photoplethysmograms [PPGs], spirograms, magnetic resonance imaging [MRI]) are valuable assets for clinical diagnosis, treatment, and prognosis and provide a unique opportunity for studying the genetic basis of complex traits.1,2,3,4,5,6,7,8,9 Recent technological progress in electronic health record (EHR)...
By Yuchen Zhou, Justin Khasentino, Taedong Yun, Mahantesh Biradar, Jacqueline Baras Shreibati, Dongbing Lai, Tae-Hwi Schwantes-An, Robert N Luben, Zachary R McCaw, Jorgen Engmann, Rui Providência, Amand Floriaan Schmidt, Patricia B Munroe, Howard Yang, Andrew Carroll, Anthony P. Khawaja, Cory Y McLean, Babak Behsaz, Farhad Hormozdiari
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The American Journal of Human Genetics
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Utilizing multimodal AI to improve genetic analyses of cardiovascular traits
Y.Z., J.C., T.Y., Z.R.M., J.B., H.Y., A.C., C.Y.M., B.B., and F.H. are current or former employees of Google, and own Alphabet stock as part of the standard compensation package. Y.Z., J.C., T.Y., Z.R.M., J.B., H.Y., A.C., C.Y.M., B.B., and F.H. are current or former employees of Google and received salary, bonus, and stock awards as part of the standard compensation package.
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications - Nature Genetics
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Abstract As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities.
By Daniel F Levey, Marco Galimberti, Joseph D. Deak, Dora Koller, Emma Johnson, Mahantesh Biradar, Max Lam, Veera M. Rajagopal, Henry R Kranzler, Howard J. Edenberg, Arpana Agrawal, Todd Lencz, David M. Hougaard, Anders D. Børglum, Ditte Demontis, Michael J. Gandal, Renato Polimanti, Murray B. Stein
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Nature
Verified
Study finds genetic screening for deafness in newborns may be beneficial
Newborn genetic screening for hearing impairment: a population-based longitudinal study A recent paper published in Genetics in Medicine highlights the importance of genetic screening in newborns for hearing impairment. Dr. Chuan Jen Hsu and his team performed screening for mutations involved in deafness and correlated the results to long-term hearing loss. The study emphasizes and justifies genetic screening for mutations in infants.
Trick or treat? Role of uric acid and central obesity on the risk of metabolic syndrome
Schematic explaining the causal role of UA on the risk of MetS, BP – Blood pressure, UA – Uric Acid, TG – Triglyceride, FSG – Fasting Glucose, WC – Waist Circumference, HDL-C - high-density lipoprotein Cholesterol. Credit: Mahantesh Biradar Metabolic syndrome is a collection of conditions that happen together, increasing your risk of heart disease, stroke and type 2 diabetes.
Trick or treat? The role of uric acid and central obesity on the risk of metabolic syndrome
Schematic explaining the causal role of UA on the risk of MetS, BP – Blood pressure, UA – Uric Acid, TG – Triglyceride, FSG – Fasting Glucose, WC – Waist Circumference, HDL-C - high-density lipoprotein Cholesterol. Credit: Mahantesh Biradar Metabolic syndrome is a collection of conditions that happen together, increasing your risk of heart disease, stroke and type 2 diabetes.
Eggshell-Derived Nano Particles Can Be Used For Drug Delivery
Eggshells are among the most commonly discarded kitchen waste. Now scientists are putting eggshells to some novel use – drug delivery – by deriving nanoparticles out of them. A team of scientists at the Indian Institute of Technology (IIT) Madras have developed a method to use eggshells for synthesizing nanoparticles. These nanoparticles could be potential candidates for local drug delivery as well as a material for bone grafts.
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