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Maike Barcik

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S1P receptor 1 signaling reduces arterial thrombosis via up-regulation of endothelial thrombomodulin expression

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By Rui Yang, Ying Yuan, Amaia Ochandorena-Saa, Marcel Benkhoff, Philipp Mourikis, Betül Knoop, Maike Barcik, Tim Huckenbeck, Gabrielle Al-Kassis, Laura Schönfelder, Jasmin Seel, Fernando Kreuz, Moritz Hering, Kajetan Trojovsky, Philipp Wollnitzke, Julia Kielb, Jessica Weber, Jéssica Weber, Thomas Ulrych, Bernhard Rauch, Susanne Pfeiler, Lisa Dannenberg, Norbert Gerdes, Tobias Zeus, Malte Kelm, Bodo Levkau
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Sphingosine-1-phosphate (S1P) is a key mediator in the cardiovascular system with controversial effects on coagulation. We hypothesized that S1P reduces platelet adhesion and thrombus formation by up-regulating endothelial thrombomodulin (TM), an antithrombotic protein.
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