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Maïlyn Yates on Muck Rack

Maïlyn Yates

As seen in: Nature, PLOS Biology, Genes and Development Journal
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Articles

RFWD3/FANCW orchestrates post-replicative filling of ssDNA gaps to promote UV tolerance

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By Lisa Casimir, Isabelle Marois, Jean-Christophe Dubois, Maïlyn Yates, Rima Kochman, Billel Djerir, Samuel Zimmer, Yosra Mehrjoo, François Bélanger, Edlie St-Hilaire, Wendy Leung, Ryan Baxley, Nadia Côté, Laurent Cappadocia, Elliot Drobetsky, Amélie Fradet-Turcotte, Stephane Coulon, Pierre-Étienne Jacques, Alexandre Marechal, Félix Racine-Brassard, Félix Goudreau, Alexandra Octaviana Szenti, Vincent Mimee, Andréanne Blondeau, Gaëlle Lescalet, Luc Gaudreau, Anja Katrin Bielinsky, Hugo Wurtele
| Nature Verified
Abstract DNA lesions can stall replication, generating ssDNA gaps that require filling to maintain genome stability. The E3 ubiquitin ligase RFWD3/FANCW targets RPA and PCNA to regulate replication dynamics and damage tolerance, but its roles in these processes and influence on cell mutability remain incompletely understood. Here, we show that RFWD3 prevents the accumulation of ssDNA gaps in UV-irradiated cells through its E3 ligase activity and interaction with RPA.
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Heterozygous RPA2 variant as a novel genetic cause of telomere biology disorders

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By Rima Kochman, Ibrahima Ba, Maïlyn Yates, Vithura Pirabakaran
| Genes and Development Journal
1,13 1UMR7258 Centre National de la Recherche Scientifique (CNRS), UMR1068 Institut National de la Santé et de la Recherche Médicale (INSERM), UM105 Aix Marseille University, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille (CRCM), Laboratoire Labellisée par la Ligue Nationale Contre le Cancer, F-13009 Marseille, France; 2U1152 INSERM, Department of Genetics, Assistance Publique-Hôpitaux de Paris, Bichat Hospital, Paris Cité University, F-75018 Paris, France;...
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SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability

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By Maïlyn Yates, Université de Sherbrooke, Isabelle Marois, Edlie St-Hilaire
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article Citation: Yates M, Marois I, St-Hilaire E, Ronato DA, Djerir B, Brochu C, et al. (2024) SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability. PLoS Biol 22(3): e3002552. https://doi.org/10.1371/journal.pbio.3002552 Academic Editor: Tanya Paull, The Univ.
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