Maiwenn Pineau

Keywords IL-2 IL-10 plasma cell differentiation mice model age-associated B cell inflammation EAE regulatory B cell PDCA-1 B cells MAF Introduction Cytokines critically shape immune responses, with the common gamma-chain (γc) family, including interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21, playing central roles.

Abstract DIS3 is the main catalytic subunit of the nuclear RNA exosome, a complex playing a crucial role in RNA processing and the degradation of various noncoding RNA substrates. In mice, DIS3 is essential for genomic rearrangements during B cell development, but its role in terminal plasma cell (PC) differentiation has not been explored. Although DIS3 gene alterations are frequent in multiple myeloma (MM), a PC malignancy, their molecular impact remains poorly understood.

Abstract While classical models of transcriptional regulation focus on transcription factors binding at promoters, gene expression is also influenced by chromosome organization. Understanding this spatial regulation strongly benefits from integrated and quantitative spatial analyses of genome-scale data such as RNA-Seq and ChIP-Seq.