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Majken Denert

As seen in: The Journal of Biological Chemistry
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Articles

Fascin Rigidity and L-plastin Flexibility Cooperate in Cancer Cell Invadopodia and Filopodia

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By Isabel Van Audenhove, Majken Denert, Ciska Boucherie, Leen Pieters, Maria Cornelissen
| The Journal of Biological Chemistry Verified
Invadopodia and filopodia are dynamic, actin-based protrusions contributing to cancer cell migration, invasion, and metastasis. The force of actin bundles is essential for their protrusive activity. The bundling protein fascin is known to play a role in both invadopodia and filopodia. As it is more and more acknowledged that functionally related proteins cooperate, it is unlikely that only fascin bundles actin in these protrusions.
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