Makeda Robinson

Yiran E. Liu1,2,3 na1, Sirle Saul3 na1, Aditya Manohar Rao1,4, 3,5, 6, Ana Maria Sanz6, Michelle Verghese5, Daniel Solis5, Mamdouh Sibai5, Chun Hong Huang5, Malaya Kumar Sahoo5, 7, Nathalia Bueno7, 7, 7, 7, Fernando Rosso6,8, Michele Donato1,9, Benjamin A.

Highlights Until recently there have been no clinically usable biomarkers to accurately predict which patients will progress to severe dengue, a major global threat. A 20-gene set that is strongly associated with the progression to severe dengue and represents a predictive signature that is generalizable across ages, host genetic factors, virus strains, and sample types was recently discovered using a multicohort analysis framework that integrates biologically heterogeneous data sets.

Highlights • A multi-cohort analysis framework revealed a 20-gene set to predict severe dengue • The 20 genes effectively predict severe dengue in existing and prospective cohorts • The 20-gene set is generalizable across ages, host genetic factors, and virus strains • The 20-gene set has potential implications for the development of a prognostic assay Summary There is a need to identify biomarkers predictive of severe dengue.