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Makenna M. Morck on Muck Rack

Makenna M. Morck

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Articles

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

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By Saswata S. Sarkar, Arjun S. Adhikari, Darshan V. Trivedi, Makenna M. Morck
| Science Magazine Verified
Abstract Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the HCM-causing mutation R663H cannot be explained by changes in fundamental myosin contractile parameters, much like the HCM-causing mutation R403Q.
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