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Saswata S. Sarkar on Muck Rack

Saswata S. Sarkar

As seen in: arXiv, Science Magazine
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Articles

[2404.06423] Deep Reinforcement Learning-Based Approach for a Single Vehicle Persistent Surveillance Problem with Fuel Constraints

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By Manav Mishra, Saswata S. Sarkar, Sujeevraja Sanjeevi, Sujit PB
| arXiv
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The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin

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By Saswata S. Sarkar, Arjun S. Adhikari, Darshan V. Trivedi, Makenna M. Morck
| Science Magazine Verified
Abstract Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the HCM-causing mutation R663H cannot be explained by changes in fundamental myosin contractile parameters, much like the HCM-causing mutation R403Q.
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Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

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By Saswata S. Sarkar, Kathleen M. Ruppel, Masataka Kawana, Shirley Sutton
| Science Magazine Verified
Hypertrophic cardiomyopathy (HCM) affects 1 in 500 individuals and is an important cause of arrhythmias and heart failure. Clinically, HCM is characterized as causing hypercontractility, and therapies are aimed toward controlling the hyperactive physiology.
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