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Malcolm White

As seen in: Nature, HuffPost UK, BioRxiv, Cell Press, Campaign (UK), The Clarion-Ledger, City AM, WARC, SooToday.com
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Articles by Malcolm White

An updated evolutionary classification of CRISPR–Cas systems including rare variants - Nature Microbiology

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By Kira S. Makarova, Yuri I. Wolf, Pascal Mutz, Emmanuelle Charpentier, Philippe Horvath, Sylvain Moineau, Patrick Pausch, Rafael Pinilla-Redondo, Shiraz A. Shah, Virginijus Siksnys, Michael P. Terns, Česlovas Venclovas, Malcolm White, Alexander F. Yakunin, Feng Zhang, Roger Garrett, Rolf Backofen, Rodolphe Barrangou
| Nature Verified
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Application of Voltage Controlled Crystal Oscillators to DC Voltage Reference Validation

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By Malcolm White, Alan Jaffe, John Lehman, Matthew Spidell
| nist.gov
, , , , Gaylon Partain DC voltage references are typically based on calibrated Zener Diodes which are subject to drift and therefore require periodic recalibration against a Primary Standard. Since it is preferable to maintain constant power to such references, the shipping and handling logistics involved in such a recalibration can present an unacceptable burden. Validation is therefore preferred, and typically accomplished by comparison against other local Zener Diodes.
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RNA processing by the CRISPR-associated NYN ribonuclease

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By Haotian Chi, Malcolm White
| BioRxiv
Abstract CRISPR-Cas systems confer adaptive immunity in prokaryotes, facilitating the recognition and destruction of invasive nucleic acids. Type III CRISPR systems comprise large, multisubunit ribonucleoprotein complexes with a catalytic Cas10 subunit. When activated by the detection of foreign RNA, Cas10 generates nucleotide signalling molecules that elicit an immune response by activating ancillary effector proteins.
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Antiviral signaling by a cyclic nucleotide activated CRISPR protease - Nature

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By Christophe Rouillon, Jonas Moecking, Martin F. Peter, Jonathan L. Schmid-Burgk, Dmitri I. Svergun, Matthias Geyer, Malcolm White, Niels Schneberger
| Nature Verified
Abstract CRISPR defense systems such as the well-known DNA-targeting Cas9 and the RNA-targeting type III systems are widespread in prokaryotes1,2. The latter can orchestrate a complex antiviral response that is initiated by the synthesis of cyclic oligoadenylates (cOAs) upon foreign RNA recognition3–5. Among a large set of proteins that were linked to type III systems and predicted to bind cOAs6,7, a CRISPR associated Lon protease (CalpL) stood out to us.
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Cyclic nucleotide-induced helical structure activates a TIR immune effector - Nature

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By Malcolm White, Gaëlle Hogrel
| Nature Verified
Abstract Cyclic nucleotide signalling is a key component of antiviral defence in all domains of life. Viral detection activates a nucleotide cyclase to generate a second messenger, resulting in activation of effector proteins. This is exemplified by the metazoan cGAS–STING innate immunity pathway1, which originated in bacteria2.
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Ombudsman declines to investigate hiring of fire chief’s son

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By Malcolm White
| SooToday.com Verified
After an initial review of complaints about Sault Fire Services' hiring last year of a relative of Fire Chief Peter Johnson, the Ontario Ombudsman has decided against proceeding with a formal investigation. Meanwhile, Malcolm White, the city's chief administrative officer, will ask City Council on Monday for changes to the hiring-of-relatives policy.
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Reconsidering bus terminal relocation will cost $30,000 and take up to six months

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By Malcolm White, David Helwig Verified
| SooToday.com Verified
Chief administrative officer warns councillors that rethinking terminal issue will take more time and money than they think City Council's new willingness to consider demolishing the downtown bus terminal at Dennis and Queen to build a new terminal there may not be as simple as councillors were thinking. In a report placed on the agenda for Monday's City Council meeting, the city's chief administrative officer says rethinking the issue will require an amended environmental process.
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Bacteria SAVED from Viruses

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By Malcolm White, St Andrews, St. Andrews
| Cell Press Verified
Increasingly, cyclic nucleotide second messengers are implicated in antiviral defense systems in bacteria and archaea as well as in eukaryotes. In this issue of Cell, Lowey et al. describe SAVED—a widespread, uncharacterized cyclic nucleotide sensor protein domain that activates cell defense systems. The structure of SAVED reveals links to the CRISPR system, which also generates cyclic nucleotides in response to viral infection.
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Back to the future: Looking back at a time when some ad men weren't sad men

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By Malcolm White
| WARC
This article opens up the theme of this new Back to the Future column, looking at how the past is relevant to today. Developing client-agency relationships United Kingdom Strategy Malcolm WhiteKrow Communications Malcolm White looks back... to a time when some ad men weren't sad men. While thinking about the past and how it is relevant to the present, which... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the future: Wheel of Fortune isn't just a game show

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By Malcolm White
| WARC
In this article, Malcolm White finds out that the Wheel of Fortune was not a term coined to name a TV show, as he finds the positives from two wins and a loss. Managing the marketing function Strategy Malcolm White finds out that the Wheel of Fortune wasn't always a game show. During the past two months, my agency has won two new clients and lost one. We didn't exactly lose... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the Future: Looking back at Rosser Reeves

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By Malcolm White
| WARC
This article looks back at the legacy of the famous American advertising executive Rosser Reeves. Back to the Future: Looking back at Rosser Reeves Malcolm White Malcolm White looks back ... at Rosser Reeves' legacy, not just his fallacy. Rosser Reeves is infamous for proposing, more than half a century ago, that a good way of proving the effect of advertising...
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Back to the future: The new courtesy

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By Malcolm White
| WARC
In this article, Malcolm White finds that a good way of renewing best business practice may lie in reverting back to an old one, when good manners was the name of the game. Back to the future: The new courtesy Malcolm Whitekrow Malcolm White on a new way of doing business based on an old way. Dear Reader... That surprised you, didn't it? When was the last time you read an article that began in this way? OK, never. Let me try...
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Back to the future: Where to find an old remedy for the pain of creative development

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By Malcolm White
| WARC
In this article, Malcolm White proposes that the industry adopts a new way of judging creative development to avoid the danger of merely conducting a taste test. Communications development research Strategy One of the reasons why clients and their agencies can find the communications development process so difficult is that it seems to come... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the future: How Denis Diderot invented behavioural economics

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By Malcolm White
| WARC
In this article, Malcolm White claims behavioural economics were, if not exactly invented, then certainly foreshadowed by French philosopher Denis Diderot. Behavioural economics Strategy Everyone's crazy about behaviour change these days. Hardly a meeting that I'm in passes without someone mentioning 'nudging', Kahneman, or giving their... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the Future: How John Keats invented virtual reality

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By Malcolm White
| WARC
In this article, Malcolm White argues that John Keats, the English Romantic poet, invented Virtual Reality. Customer experience Strategy OK, that's not strictly true. Actually, it's not true at all. But it made you want to read on, didn't it? Or perhaps not? According to surveys, if you're a regular... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the Future: The problem of premature evaluation

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By Malcolm White
| WARC
This article examines the continued relevance of the 1974 book 'Testing to Destruction' by Alan Hedges. Back to the Future: The problem of premature evaluation Malcolm White Malcolm White looks back ... to 1974 I've just come out of a dispiriting advertising research briefing and I wish I could time-travel back to 1974. The briefing was dispiriting because...
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Fiat 500: The motherhood feat

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By Malcolm White
| WARC
This case study describes how Fiat, the car manufacturer, created an online video to promote its Fiat 500L model, targeting UK mothers. Fiat 500: The motherhood feat Malcolm WhiteKrow Summary This story has it all. Sex. Well, the consequences of it Drugs. Ok, more likely to be Calpol. And controversy. Was the idea of 'The Motherhood feat. 500L' a rip-off of Toyota USs' 'Swagger Waggon'? We'll...
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Back to the future: Why you've probably never heard of Ernest Dichter

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By Malcolm White
| WARC
This article assesses the legacy, or lack thereof, left by the motivation researcher Ernest Dichter. Back to the future: Why you've probably never heard of Ernest Dichter Malcolm White Malcolm White looks back ... at Ernest Dichter and the feud that explains why you've probably never heard of him. If I were to suggest that almost every conversation you...
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Back to the Future: A bad interview saved by a good CQ

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By Malcolm White
| WARC
This article explores the idea of people's Curiosity Quotient (CQ) and why it is important that it is nourished and exercised. Talent, skills, HR Strategy I haven't actually kept count, but I reckon I have probably interviewed a couple of hundred people over the past twenty years for various advertising positions. Mostly... WARC subscribers can sign in to keep reading Not a subscriber?
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Back to the Future: Brands and birds' nests

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By Malcolm White
| WARC
In this article, Malcolm White uses an ornithological metaphor to explain how important brand-building can be - in spite of not being very keen on birds. Brand equity & strength Brand positioning Strategy This may come as a shock to the keen ornithologists among you, but I've never much liked birds. Maybe it's because I saw Alfred Hitchcock's classic and terrifying film The Birdsat too young an... WARC subscribers can sign in to keep reading Not a subscriber?
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Mississippi Writers Trail builds on success of cultural markers and book festival, honors state’s legacy

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By Malcolm White
| The Clarion-Ledger Verified
If it weren’t for a Mississippi Freedom Trail marker, you might not know that a section of Jackson’s Capitol Street was once the scene of a significant civil rights protest, Woolworth’s sit-in. If it weren’t for a Mississippi Blues Trail marker, you might not know that Club Ebony in Indianola was once owned by B.B. King and showcased legendary acts such as Ray Charles, Little Milton and B.B. King himself.
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Back to the Future: Dirty old books | WARC

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By Malcolm White
| WARC
Malcolm White believes that marketing communications should strive to be useful, rather than entertaining, which could also have the knock-on effect of making what marketers and communicators do be regarded as more useful, and maybe more valuable, too. I'm very keen on books. Not that I'm a bibliokleptomaniac (a compulsive book-stealer), nor a bibliophagist (book-eater), and certainly not a bibliotaphist (a book-burier), you understand. Bibliomaniac suits me fine, thank you.
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Venn's diagrams should be used as creative thinking tools | WARC

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By Malcolm White
| WARC
The eponymous Venn diagram should not be seen as a mere PowerPoint decoration but, Malcolm White explains, can and should be used as a creative thinking tool to unlock potential or seize opportunities. Circles have encircled me this week. Intersecting circles to be precise. During four different meetings with four different clients to discuss four different topics, I have found myself staring at the intersecting circumferences of four different Venn diagrams.
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Back to the future: Advertising and the impostor syndrome | WARC

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By Malcolm White
| WARC
Malcolm White argues  that the diminishing respect being afforded the advertising industry by clients has led it to develop a form of 'impostor syndrome'.
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Is your favourite technology actually pathological? | WARC

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By Malcolm White
| WARC
Like the Zeppelins of old, many of today’s technologies fit a ‘pathological’ profile, argues Malcolm White, and more of us need to take control of the way we use our tech, instead of being used by it. Here in London, there is a commemorative plaque which reads: 'These premises were totally destroyed by a Zeppelin raid during the World War on September 8th 1915.
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The light in the dark Satanic Mills | WARC

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By Malcolm White
| WARC
When it comes to addressing the work-life balance, Malcolm White believes advertising should take a leaf out of William Morris’s book and find ways to make work more satisfying, instead of just encouraging people to work more flexibly.
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The original fake news story | WARC

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By Malcolm White
| WARC
Malcolm White discovers the truth about a legend of broadcasting history, and finds that the only hysteria caused by the 1938 broadcast of ‘The War of the Worlds’ was the one cooked about by a competing medium - newspapers. Almost eighty years ago, at 8.30pm on 30 October 1938, 'The Mercury Theatre on the Air' radio series broadcast a one-off adaptation of H.G. Wells' classic 1897 novel The War of the Worlds, starring Orson Welles, to an unsuspecting Depression-era America.
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Is communication a bad thing | WARC

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By Malcolm White
| WARC
Malcolm White wonders how more communication went from being the force for good that would bring humanity together, to being something altogether more divisive. In 1892, William Harben published a short story, rarely anthologised today, called In the Year Ten Thousand, which, you've guessed it, is set in the year 10,000 AD.
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Could crowdsourcing be advertising's own fake news?

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By Malcolm White
| WARC
Malcolm White wonders if marketing's love affair with crowdsourcing is creating a fake news problem for commercial creativity. He looks back 600 years to a lesser known work of Chaucer for guidance. At the end of the fourteenth century, the father of English poetry, Geoffrey Chaucer, wrote a long poem called The House of Fame. It’s nowhere near as famous as The Canterbury Tales, but it's well worth a read. Go on, surprise yourself, read something medieval today.
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The positive power of negative thinking

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By Malcolm White
| WARC
Long ago, I had an interview in New York with a well-known advertising agency. In the last of a round of interviews, the head of human resources used a phrase that I've heard with increasing frequency over the intervening years.
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For boomers: Bill Maher, Paul Thorn

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By Malcolm White
| The Clarion-Ledger Verified
A link has been posted to your Facebook feed. Don’t expect any minced words. Bill Maher, stand-up comedian, TV host and political commentator, will play Thalia Mara Hall. The host of HBO’s “Real Time” and before that, “Politically Incorrect” on Comedy Central and ABC, promises a show that’s outspoken on politics and social issues.
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For boomers: Sanderson Farms Championship, film fest

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By Malcolm White
| The Clarion-Ledger Verified
A link has been posted to your Facebook feed. Hollywood hasn't cornered the market on red-carpet events. The Mississippi International Film Festival is at Tinseltown in Pearl Saturday, and starting at 11 a.m., the films will be rolling. Mississippi's own Lance Bass, of N'Sync fame, will be there at 7 p.m. receiving honors from the state and showing his film "Mississippi: I Am." Details: Visit msfilm.org for all the info. Tee up for this event.
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For boomers: Scare up a good time at Halloween parties

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By Malcolm White
| The Clarion-Ledger Verified
A link has been posted to your Facebook feed. Check out the Growl-O-Ween Gala and WitchCrafted Monster Bash for Halloween night. Fondren Theatre Workshop will present some haunting, hilarious monologues and musical numbers at the Growl-O-Ween Gala costume party at Capitol Grill. There will be a costume contest, a selfie station and door prizes. There’s no cover, but a donation of a bag of dog food is requested for Cheshire Abbey, which will also benefit from a silent auction at the event.
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For boomers: 'All The Way', Red Beans & Rice Fest

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By Malcolm White
| The Clarion-Ledger Verified
Check out 'All The Way' at New Stage Theatre and head over to the Trustmark Red Beans and Rice Festival. History buffs and theater fans, this is a New Stage Theatre production you don't want to miss. The Tony Award-winning "All The Way" takes the audience through key points of the 1960s, including signing of civil rights legislation, increasing involvement in Vietnam and more. The Rev. Martin Luther King Jr., Sen. Hubert Humphrey and Lyndon B.
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