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Malea M. Murphy

As seen in: Nature, Cell Press
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Articles

Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor - Nature Cell Biology

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By Malea M. Murphy, Jessalyn M. Ubellacker, Genevieve M. Crane, Shentong Fang, Zhiyu Zhao, Bo Shen
| Nature Verified
Abstract The bone marrow contains peripheral nerves that promote haematopoietic regeneration after irradiation or chemotherapy (myeloablation), but little is known about how this is regulated. Here we found that nerve growth factor (NGF) produced by leptin receptor-expressing (LepR+) stromal cells is required to maintain nerve fibres in adult bone marrow. In nerveless bone marrow, steady-state haematopoiesis was normal but haematopoietic and vascular regeneration were impaired after myeloablation.
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Endothelial and Leptin Receptor+ cells promote the maintenance of stem cells and hematopoiesis in early postnatal murine bone marrow

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By Nergis Kara, Yuanyuan Xue, Zhiyu Zhao, Malea M. Murphy
| Cell Press Verified
Antibodies Purified Rat α-Mouse CD16/CD32 (Mouse BD Fc Block™) BD Biosciences Cat.
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A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

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By Bo Shen, Alpaslan Tasdogan, Malea M. Murphy, Yunduo C. Zhao
| Nature Verified
Abstract Stromal cells in adult bone marrow that express leptin receptor (LEPR) are a critical source of growth factors, including stem cell factor (SCF), for the maintenance of haematopoietic stem cells and early restricted progenitors1,2,3,4,5,6. LEPR+ cells are heterogeneous, including skeletal stem cells and osteogenic and adipogenic progenitors7,8,9,10,11,12, although few markers have been available to distinguish these subsets or to compare their functions.
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