Malene Heilskov Veje

Understanding and measuring fluid shear stress in stirred tank bioreactors is crucial in bioreactor development and process scale-up (Gareau et al., 2014; Kamen et al., 1992). Fluid shear stress results from mechanical agitation through impellers and gas bubbles arising from aeration. Its magnitude depends on many factors such as rotational speed of the impeller, geometry of the bioreactor vessel and impeller, and viscosity of cell culture.