Mallory Paynich Murray on Muck Rack

Mallory Paynich Murray

As seen in: Cell Reports
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Articles

Stimulation of a subset of natural killer T cells by CD103+ DC is required for GM-CSF and protection from pneumococcal infection

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By Catherine M. Crosby, Paola Marcovecchio, Mallory Paynich Murray
| Cell Reports Verified
Highlights • Natural killer T cells (NKT cells) protect mice from pneumococcal infection • NKT and γδ T cells are rapidly activated and recruited from the vasculature • A type of dendritic cell that produces IL-23 activates these innate-like T cells • An NKT cell subset that exclusively produces GM-CSF is required for protection Summary Innate-like T cells, including invariant natural killer T cells, mucosal-associated invariant T cells, and γδ T cells, are present in various barrier tissues,...
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