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Mandy Barthel

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Articles

Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes

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By Lena Jassowicz, Fangyoumin Feng, Rolf Warta, Fatima Heinicke, Amélie Wöllner, Hannah Briesch, Furkan Sor, Julia Soller, Catharina Lotsch, John Wong, Chang-Gyun Park, Nicolas Aubert, Maximilian Scheer, Zhaoqing Hu, Maximilian Knoll, Julian Schlegel, Lukas Frank, Philip Dao Trong, Gerhard Jungwirth, Amin Nohman, Kendra K. Maaß, Niels Grabe, Mandy Barthel, Simone Butz, Christina Lulay, Manuela Zucknick, Michele Bortolomeazzi, Pooja Sant, Verena Thewes, Laura Michel, Carlo Fremd, Andreas Schneeweiss, Chong Sun, Karsten Rippe, Amir Abdollahi, Andreas von Deimling, Andreas W. Unterberg, Sandro M. Krieg, Jan-Philipp Mallm, Peter Lichter, Marc Zapatka, Martina Seiffert, Christel Herold-Mende
| Cell Press Verified
Keywords brain metastases breast cancer immunotherapy tumor microenvironment single-cell analysis biomarkers tissue-resident memory T cells tertiary lymphoid structures spatial neighborhood, tumor organoids Introduction Breast cancer (BC) is the most common cancer in women and a highly heterogeneous disease.1,2 Systemic therapy is closely tailored to the main subtypes—luminal BC, human epidermal growth factor receptor 2 (HER2)-enriched BC, and triple-negative BC (TNBC).2 Despite significant...
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