Manfred Josef Oswald

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-023-01291-x, published online 6 April 2023. In the version of the article initially published, the “Inflammatory pain (CFA)” image in Extended Data Fig. 5e was duplicated from the “Laser ON” image in Extended Data Fig. 4d. Extended Data Fig. 5e has now been amended with an image from the correct experimental group in the HTML and PDF versions of the article.

Abstract A painful episode can lead to a life-long increase in an individual’s experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhance pain. Here, we show in mice that long-term associative fear memory stored in neuronal engrams in the prefrontal cortex determines whether a painful episode shapes pain experience later in life.

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