Manik Sharma on Muck Rack

Manik Sharma

Verified
India
As seen in: Path of EX, MSN India, Wiley Online Library, Yahoo Canada, Hindustan Times, Frontiers, The Indian Express, ACS Publications, Firstpost, Flipboard, Outlook (India) and
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Articles

Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases Click to copy article link Article link copied!

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By Manik Sharma , Kyle F. Biegasiewicz
| dx.doi.org
Triazolopyridines are an important class of heterocyclic compounds in medicinal chemistry and the materials industry. (1−3) Among these, [1,2,3]triazolo[1,5a]pyridines have emerged as antiparasitic agents for Chagas disease treatment, (4,5) and stable carbene precursors for accessing pyridyl diazo intermediates through ring–chain isomerization in chemocatalysis, (1,6) and biocatalysis (Figure 1a).
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Biocatalytic Synthesis of Isoxazolines Enabled by Cryptic Nitrile Oxide Formation by a Vanadium-Dependent Chloroperoxidase

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By Manik Sharma , Kyle F. Biegasiewicz
| Wiley Online Library
ManikSharma and and Kyle F.Biegasiewicz, Angewandte Chemie International Edition ((2026): e24817, https://doi.org/10.1002/anie.202524817. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article.
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From AI Experiments to Operational Impact: What It Really Takes for Enterprises to Realize Value

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By Manik Sharma 
| Logistics Viewpoints
For the past several years, artificial intelligence has been everywhere in enterprise conversations and nowhere in actual results. Most organizations have experimented, many have piloted, but very few have operationalized AI in a way that meaningfully moves the needle. In fact, the numbers tell a sobering story: the vast majority of enterprise AI initiatives fail to deliver tangible business value, with estimates suggesting as many as 80 to 95% fall short of expectations.
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