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Manikarna Dinda on Muck Rack

Manikarna Dinda

As seen in: PLOS, The Journal of Biological Chemistry
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Articles

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III

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By Manikarna Dinda, Ryan Fine, Shekhar Saha, Zhenjia Wang
| PLOS
Cohibin and Fob1 dictate the conformation of chromosomes III and XII Given the requirements for cohibin and Fob1 in condensin recruitment to the RDT1 promoter on chrIII and the rDNA on chrXII, and their similar contributions to donor preference, we hypothesized that deleting LRS4 or FOB1 should significantly disrupt the structure of both chromosomes. Genome-wide chromatin contacts were analyzed by Micro-C XL [49].
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Pausing sites of RNA polymerase II on actively transcribed genes are enriched in DNA double-stranded breaks

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By Arkadi Manukyan, Heather M Raimer, Manikarna Dinda, Stefan Bekiranov and
| The Journal of Biological Chemistry Verified
Abstract DNA double-stranded breaks (DSBs) are strongly associated with active transcription, and promoter-proximal pausing of RNA polymerase II (Pol II) is a critical step in transcriptional regulation. Mapping the distribution of DSBs along actively expressed genes and identifying the location of DSBs relative to pausing sites can provide mechanistic insights into transcriptional regulation.
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