Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Abstract Phenotypic plasticity is a hallmark of cancer1; however the molecular switches required for cell-fate reprogramming are poorly understood. During intestinal wound-healing and colorectal cancer (CRC) metastasis, differentiated cells can dynamically dedifferentiate into an intestinal stem cell (ISC) state to drive epithelial regeneration and metastatic outgrowth2,3,4,5,6,7,8,9,10.
Keywords peritoneal carcinomatosis appendiceal cancer organoids mouse model intratumor heterogeneity growth factor dependencies genomics targeted therapies KRAS inhibitor Introduction The peritoneal cavity is a common site of metastasis from advanced gastrointestinal and gynecological malignancies; up to 70% of patients present with peritoneal carcinomatosis (PC) at the time of metastatic diagnosis.1,2,3 PC can lead to the loss of intestinal peristalsis and organ failure, and poor overall...
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
