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Michael Foote

New York
As seen in: Brief Recess: A Legal Podcast with Michael Foote & Mélissa Malebranche, Nature, The Hill, JAMA (The Journal of the American Medical Association), JAMA Oncology, AZCentral | The Arizona Republic, Medscape, The Denver Post, Cell Press, Podchaser, ONCOLOGY journal and
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Articles

An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis

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By Ahmed Mahmoud, Christine Sukhwa, Michael Giarrizzo, Philip H. Choi, Jura Pintar, Henry Walch, Nan Zhao, Jonathan Bermeo, Sebastian K. Chung, Manisha Raghavan, Samhita Bapat, Qingwen Jiang, Julia Meredith, Canan Firat, Andrea Cercek, Michael Foote, Nikolaus Schultz, Walid K. Chatila, Garrett M. Nash, Jinru Shia, Francisco Sanchez-Vega, Steven M. Larson, Arvin C. Dar, Neal Rosen, Georgios Karagkounis, Karuna Ganesh
| Cell Press Verified
Keywords peritoneal carcinomatosis appendiceal cancer organoids mouse model intratumor heterogeneity growth factor dependencies genomics targeted therapies KRAS inhibitor Introduction The peritoneal cavity is a common site of metastasis from advanced gastrointestinal and gynecological malignancies; up to 70% of patients present with peritoneal carcinomatosis (PC) at the time of metastatic diagnosis.1,2,3 PC can lead to the loss of intestinal peristalsis and organ failure, and poor overall...
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Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial

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By Wungki Park, Catherine A. O’Connor, Joanne F. Chou, Marc Hilmi, Zeynep Tarcan, Carly Schwartz, Mary Larsen Verified, Karthigayini Sivaprakasam, Shigeaki Umeda, Maria Perry, Anna Varghese, Fiyinfolu Balogun, Alice Zervoudakis, Seth Katz, Tae-Hyung Kim, Ken Zhao, Allison Richards, Nicolas Lecomte, Daniel Muldoon, Walid K. Chatila, Jessica Yang, Devika Rao Verified, Smita Joshi, Michael Foote, James Harding Verified, Andrew Epstein, David P. Kelsen, Fergus Keane, Joshua D. Schoenfeld, Anupriya Singhal, Erin DiGuglielmo, Chaitanya Bandlamudi, Junmin Song, Haochen Zhang, Maria Teresa Lao, Jerry P Melchor, Ronak Shah, Wenfei Kang, Francesca Mazzoni, Kevin C. Soares, Ernesto Santos, Vineet S. Rolston, Marsha Reyngold, Alice Wei, Murray J. Tipping, Olca Basturk, Michael Berger, Mark Schattner, William R. Jarnagin, Nadeem Riaz, Vinod P. Balachandran, Dana Pe’er, Marinela Capanu, Eileen M. O’Reilly, Ramzi Homsi, Elias Karnoub, Imane El-Dika, Ryan Sugarman, Sree Chalassani, Hulya Sahin Ozkan, Junguei Hong, Agustin III Cardenas, Mark TA Donoghue, Richard Kihn Do, Christine Iacobuzio-Donahue
| Nature Verified
Abstract Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum chemotherapy and PARP inhibition in pancreatic cancer (PC) and may enable prolonged disease control with immune checkpoint blockade (ICB). The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib following platinum-based chemotherapy in biomarker-stratified metastatic PC.
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Brief Recess: A Legal Podcast with Michael Foote & Mélissa Malebranche

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By Michael Foote, Mélissa Malebranche
| Podchaser
What happens when your Uber driver gets pulled over while you're in the backseat? How do OnlyFans creators incorporate an LLC to remain anonymous? How can you fight ICE without getting off the couch? Welcome to Brief Recess, hosted by everyone's favorite TikTok lawyer Michael Foote and his best friend Mélissa Malebranche.
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