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Articles by Manyu Chen
Ameliorative effects and mechanisms of paeonol against rosacea through network pharmacology and experimental validation
Abstract Rosacea is a long-term and relapsing inflammatory skin disorder resulting from dysfunction of the immune and/or neurovascular systems. Paeonol (Pae), the primary active component extracted from Moutan Cortex, exhibits various pharmacological effects, including anti-inflammatory and antioxidant properties. This study aimed to evaluate the therapeutic efficacy of Paeonol in treating rosacea and to investigate the underlying mechanisms of its action.
Virtual screening identifies specnuezhenide as a potential therapeutic agent for rosacea via KLK5/TLR4/NF-κB pathway inhibition and metabolic modulation
Abstract Background: Rosacea is a chronic inflammatory skin condition. Excessive LL-37 is produced when serine protease kallikrein-5 (KLK5) is hyperactivated, contributing to the inflammatory response in rosacea. Thus, inhibition of KLK5 has the potential to attenuate inflammation in this condition. Reports suggest that specnuezhenide (Spe), an isomer of oleanolic acid, is effective as an anti-inflammatory agent for the treatment of inflammatory diseases.
Frontiers | Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism
1 Introduction Rosacea is a chronic inflammatory skin condition characterized by chronic erythema, flushing, inflammation, papules, pustules, and pigmented changes, primarily affecting the central part of the face. Patients with rosacea often present with a severe negative impact on their state of life, self-esteem, and general well-being (1).
Hydrogen-Bond-Mediated Through-Space Conjugation for the Fabrication of Red-Emissive Solid-State Carbon Dots and Application in LEDs
Abstract Click to copy section linkSection link copied! Solid-state red-emissive carbon dots (CDs) resistant to aggregation-caused quenching are highly desirable for optoelectronic materials. Here, Pd and N codoped carbon dots (CDs-N/Pd) were synthesized via a hydrothermal method using 4-aminophenylacetylene as the carbon source and PdCl2 as the dopant.
Self‐Assembled Bifunctional Exosomes Simplify Chondrocyte‐Targeted Sustained‐Release Systems in Decellularized Cartilage Microgels for Synergistic Osteoarthritis Therapy
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll70264-sup-0001-SuppMat.docx1.4 MB Supporting Information References 1, , , , , , , , , , Nat. Rev. Rheumatol. 2020, 17, 59. 2, , , Nat. Rev. Rheumatol. 2020, 17, 47. 3, , , , , , , , , , , , , Nat. Commun. 2023, 14, 3159. 4, , , , , , , Allergy 2019, 75, 561. 5, , , Nat. Rev. Rheumatol. 2020, 16, 673. 6, , , , , , , , , , Bone Res. 2020, 8, 25. 7, Annu. Rev. Physiol. 2015, 77, 13.
Microenvironment-responsive release of Mg2+ from tannic acid decorated and multilevel crosslinked hydrogel accelerates infected wound healing
Microenvironment-responsive release of Mg2+ from tannic acid decorated and multilevel crosslinked hydrogel accelerates infected wound healing The management of chronic infected wounds poses significant challenges due to frequent bacterial infections, high concentrations of reactive oxygen species, abnormal immune regulation, and impaired angiogenesis. This study introduces a novel, microenvironment-responsive, dual dynamic, and covalently bonded hydrogel, termed OHA-P-TA/G/Mg2+.
Optimising Ion Conductivity in NdBaInO4-Based Phases
1. Introduction Solid oxide materials with high oxide-ion conductivity and proton conductivity have been widely applied to many technological applications such as oxygen separation membranes, PCECs, and solid oxide fuel cells (SOFCs) [1,2,3,4,5,6,7,8,9,10], thus they have attracted a great deal of interest. The most investigated oxygen-ion and proton conductors are complex oxides with perovskite structures.
Optimising Ion Conductivity in NdBaInO4 Based Phases
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 7 March 2024 / Approved: 8 March 2024 / Online: 11 March 2024 (02:13:11 CET) Chen, M.; Li, C.; Zhu, K.; Wang, J.; Liu, S.; Kong, W.; Ban, Z.; Shen, C. Optimising Ion Conductivity in NdBaInO4 Based Phases. Preprints 2024, 2024030539. https://doi.org/10.20944/preprints202403.0539.v1 Chen, M.; Li, C.; Zhu, K.; Wang, J.; Liu, S.; Kong, W.; Ban, Z.; Shen, C. Optimising Ion Conductivity in NdBaInO4 Based Phases.
Correction to“Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy”
Adv. Mater., 2024, 36, 2312559 DOI: 10.1002/adma.202312559 Corrected Figure 1B: Figure 1 B) TEM images of Lipsome, CAP/EXO, and CAP/hyEXO. Scale bar = 200 nm. Corrected Figure 2B,C: We apologize for this error.
Injectable Microgels with Hybrid Exosomes of Chondrocyte‐Targeted FGF18 Gene‐Editing and Self‐Renewable Lubrication for Osteoarthritis Therapy
Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA). However, the clinical translation of FGF18-based protein drugs is hindered by their short half-life, low delivery efficiency and the need for repeated articular injections.
Nomogram-based prediction model for the risk of DKD
Back to Journals » Diabetes, Metabolic Syndrome and Obesity » Volume 17 Authors Wang X, Liu X, Zhao J, Chen M, Wang L Received 3 October 2023 Accepted for publication 23 December 2023 Published 12 January 2024 Volume 2024:17 Pages 215—225 DOI https://doi.org/10.2147/DMSO.S442925 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Konstantinos Tziomalos Xian Wang,1 Xiaming Liu,1 Jun Zhao,1 Manyu Chen,1 Lidong Wang2...
Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202304308-sup-0001-SuppMat.pdf1.5 MB Supporting Information adfm202304308-sup-0002-MovieS1.mp413.4 MB Supplemental Movie 1 adfm202304308-sup-0003-MovieS2.mp410.6 MB Supplemental Movie 2 References 1, , , , , Sci. Transl. Med. 2019, 11, aau7411. 2, , , , , , , , , , Sci. Adv. 2020, 6, abc470. 3, , Lancet Oncol. 2010, 11, 1001. 4, , , , , , , , , , Theranostics 2020, 10, 4779.
Highly Malleable Personalized Prostheses with Hierarchical Microstructure Boost the Long‐Term Osteointegration in Irregular Craniofacial Reconstruction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202304308-sup-0001-SuppMat.pdf1.5 MB Supporting Information adfm202304308-sup-0002-MovieS1.mp413.4 MB Supplemental Movie 1 adfm202304308-sup-0003-MovieS2.mp410.6 MB Supplemental Movie 2 References 1, , , , , Sci. Transl. Med. 2019, 11, aau7411. 2, , , , , , , , , , Sci. Adv. 2020, 6, abc470. 3, , Lancet Oncol. 2010, 11, 1001. 4, , , , , , , , , , Theranostics 2020, 10, 4779.
Applications of Polyacetylene Derivatives in Gas and Liquid Separation
1. Introduction With the improvement in people’s living standards and the growth of the population, people’s demand for energy is growing, which greatly promotes the rapid development of the chemical industry. However, the chemical industry inevitably releases carbon monoxide, carbon dioxide, volatile organic compound (VOC) gas and a large number of organic solvent mixture while achieving high value output, leading to global warming, water pollution and severe weather with frequent disasters.
Copolymers of 4-Trimethylsilyl Diphenyl Acetylene and 1-Trimethylsilyl-1-Propyne: Polymer Synthesis and Luminescent Property Adjustment
Abstract : Poly(4-trimethylsilyl diphenyl acetylene) (PTMSDPA) has strong fluorescence emission, but its application is limited by the effect of aggregation-caused quenching (ACQ). Copolymerization is a commonly used method to adjust the properties of polymers.
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