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Articles by Maohan Su
Mitotic Cdc42 waves encode PI(3,4)P 2 signaling and Golgi morphological state to control spindle scaling
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Self-organizing waves are observed in numerous biological systems and may encode spatial and temporal information for cellular organization in the absence of prepatterns.
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology
Abstract Biomolecular condensates are membraneless bodies that organize biochemical reactions typically within cells. However, the roles of condensates in extracellular space—where conditions differ substantially from intracellular space—remain poorly understood. Here we report that mast cell extracellular granules (MCEGs), a stable membraneless entity, are condensates assembled through electrostatic interactions between glycosaminoglycans and polyamines.
The Golgi Rim is a Precise Tetraplex of Golgin Proteins that Can Self-Assemble into Filamentous Bands
Abstract Golgin proteins have long been suspected to be organizers of the Golgi stack. Using three-dimensional super-resolution microscopy, we comprehensively localize the human golgin family at the rim of the Golgi apparatus at 10-20 nm resolution in situ. Unexpectedly, we find that the golgins are precisely organized into a tetraplex with four discrete layers, each containing a specific set of rim golgins. We observe no golgins inside the stack between its membrane-bound cisternae.
Competition and synergy of Arp2/3 and formins in nucleating actin waves
Highlights • Formins (FMNL1 and mDia3) are recruited to cortical actin waves prior to Arp2/3 • Waves of Cdc42 and active FMNL1 can occur in the absence of actin waves • FMNL1 and Arp2/3 compete with each other for access to active Cdc42 • Arp2/3 clusters SHIP1 and negatively regulates Cdc42 Summary Actin assembly and dynamics are crucial for maintaining cell structure and changing physiological states.
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging
Mapping the intricate spatial relationships between the many different molecules inside a cell is essential to understanding cellular functions in all their complexity. Super-resolution fluorescence microscopy offers the required spatial resolution but struggles to reveal more than four different targets simultaneously. Exchanging labels in subsequent imaging rounds for multiplexed imaging extends this number but is limited by its low throughput.
Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves
Abstract The assembly and disassembly of actin filaments and their regulatory proteins are crucial for maintaining cell structure or changing physiological state. However, because of the tremendous global impact of actin on diverse cellular processes, dissecting the specific role of actin regulatory proteins remains challenging.
Collective dynamics of formin and microtubule and its crosstalk mediated by FHDC1
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PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection - Nature
Abstract Understanding protective immunity to COVID-19 facilitates preparedness for future pandemics and combats new SARS-CoV-2 variants emerging in the human population. Neutralizing antibodies have been widely studied; however, on the basis of large-scale exome sequencing of protected versus severely ill patients with COVID-19, local cell-autonomous defence is also crucial1,2,3,4.
Unraveling cellular complexity with unlimited multiplexed super-resolution imaging
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Membrane shape-mediated wave propagation of cortical protein dynamics
Our model is based on the notion that membrane shape feeds back with cortical protein recruitment19,21,29,30. Such feedback can generate wave behavior30, and similar ideas have been proposed to account for traveling waves in other systems29,31. Here we set out to explore how such concept plays out in our own system. We aimed to construct a minimal model—including the most essential components as demonstrated by existing experiments4—to recapitulate the basic phenomena of our traveling waves (Fig.
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