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Tyrosine kinase inhibitors in Kosaki/Penttinen syndromes: new reports, follow-up of treated individuals and literature review
Abstract Heterozygous activating variants in platelet-derived growth factor receptor beta (PDGFRβ) are associated with ultra-rare and clinically heterogeneous conditions, including KOGS (Kosaki Overgrowth Syndrome), PS (Penttinen Syndrome) and related conditons. Tyrosine kinase inhibitors (TKIs), which are widely used in hematological and oncological diseases, are now being explored as potential treatments for these conditions.
Risk of cervical cancer and high-grade lesions in vulnerable women a systematic review and meta-analysis - Nature Communications
Abstract Cervical cancer is largely preventable, yet causes around 300,000 deaths annually, disproportionately affecting vulnerable women. In here, we aim to estimate the risk of high-grade cervical lesions and cervical cancer among vulnerable populations in high- and upper-middle-income countries. We conduct a systematic review and meta-analysis of studies published up to February 2024 (from 2004 for HIV) across four databases. Risk of bias is assessed using the Newcastle–Ottawa Scale.
la santé des femmes, un enjeu démocratique menacé
TRIBUNE - Le cancer du col de l'utérus illustre les inégalités en santé qui menacent les femmes en Europe. De véritables progrès sont possibles, mais ils restent fragiles. Le Pr Marc Bardou est chercheur Inserm au centre d'investigations cliniques du CHU Dijon‐Bourgogne, coordonnateur des projets européens sur la prévention du cancer du col de l'utérus, CBIG-SCREEN (https://cbig-screen.eu) et HPV-FASTER-implement (https://www.hpv-faster-implement.eu).
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