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Marco Barazas on Muck Rack

Marco Barazas

As seen in: Nature, BioRxiv, Cell Press
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Articles

A mutational scar-based genome-wide map of DNA double-strand break repair

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By Marco Barazas, Robin van Schendel, Marcel Tijsterman
| Nature Verified
Abstract Genome alterations arise from inaccurate DNA repair and accumulate as distinct mutational signatures. Here, we systematically interrogate the contribution of every protein-coding gene to double-strand break (DSB) repair by generating high-resolution outcome profiles following gene knockouts.
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MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis

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By Colm Seale, Marco Barazas, Robin van Schendel, Marcel Tijsterman
| BioRxiv
Abstract Motivation: Understanding the factors involved in DNA double-strand break (DSB) repair is crucial for the development of targeted anti-cancer therapies, yet the roles of many genes remain unclear. Recent studies show that perturbations of certain genes can alter the distribution of sequence-specific mutations left behind after DSB repair.
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Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors

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By Marco Barazas, Alessia Gasparini, YiKe Huang, Stefano Annunziato
| cancerres.aacrjournals.org
Priority Reports Marco Barazas, Alessia Gasparini, Yike Huang, Asli Küçükosmanoğlu, Stefano Annunziato, Peter Bouwman, Wendy Sol, Ariena Kersbergen, Natalie Proost, Renske de Korte-Grimmerink, Marieke van de Ven, Jos Jonkers, Gerben R. Borst and Sven Rottenberg DOI: 10.1158/0008-5472.CAN-18-2077 Published February 2019 Abstract The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP inhibitors.
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