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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence
Highlights • Substance P inhibition improves corneal wound healing and transparency • Substance P aggravates corneal SCD by stimulation of mTOR pathway and cell senescence • Corneal epithelial stem cells express NK1R • Topical NK1R antagonists represents an attractive option to treat corneal SCD Summary Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is accompanied by defective healing.
STAT3 precedes HIF1α transcriptional responses to oxygen and oxygen and glucose deprivation in human brain pericytes
Brain pericytes are important to maintain vascular integrity of the neurovascular unit under both physiological and ischemic conditions. Ischemic stroke is known to induce an inflammatory and hypoxic response due to the lack of oxygen and glucose in the brain tissue. How this early response to ischemia is molecularly regulated in pericytes is largely unknown and may be of importance for future therapeutic targets.
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