Romina Lasagni Vitar on Muck Rack

Romina Lasagni Vitar

As seen in: Stem Cell Reports
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Articles

Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence

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By Bykova T.V, Romina Lasagni Vitar, Francesca Triani, Marco Barbariga, Giulio Ferrari, Philippe Fonteyne, Paolo Rama
| Stem Cell Reports Verified
Highlights • Substance P inhibition improves corneal wound healing and transparency • Substance P aggravates corneal SCD by stimulation of mTOR pathway and cell senescence • Corneal epithelial stem cells express NK1R • Topical NK1R antagonists represents an attractive option to treat corneal SCD Summary Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is accompanied by defective healing.
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