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Marco Barreca on Muck Rack

Marco Barreca

As seen in: Nature, BioRxiv
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Articles

Pan-cancer multi-omic integration of Trop2 reveals biological determinants and translational implications for ADC therapy

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By Giulia Notini, Barbara Galbardi, Giulia Viale, Matteo M. Naldini, Carlo Bosi, Giacomo De Micheli, Luca Licata, Marco Mariani, Marta Piras, Carmen Criscitiello, Marco Barreca, Maurizio Callari, Caterina Zanibelli, Francesca Patanè, Antonella Chiavassa, Jose Perez-Garcia, H. Ali, Javier Cortés, Lajos Pusztai, Luca Gianni, Giampaolo Bianchini, Matteo Dugo
| Nature Verified
Abstract Trop2–directed antibody-drug conjugates (ADCs) show activity across epithelial cancers, yet determinants of target expression in tumors and normal tissues remain poorly defined. We integrated bulk and single-cell transcriptomic profiles from over 20,000 samples across TCGA, GTEx and public atlases to map TACSTD2 expression, regulation and functional correlates in solid malignancies and healthy epithelia.
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Spin Coupling in Symmetric and Asymmetric Allyl and Phenalenyl Diradicals Bridged by an Inverted Singlet–Triplet System

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By Marco Barreca, Francesco Di Maiolo
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Optically addressable electron spins that can be initialized and detected using light constitute promising candidates for qubits.
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Particle–Hole Symmetry Breaking in Nitrogen-Decorated Triphenylmethyl Radical Emitters

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By Alessio Rizzo, Marco Barreca, Francesco Di Maiolo
| dx.doi.org
1. Introduction Click to copy section linkSection link copied! Organic light-emitting diodes (OLEDs) have conventionally employed closed-shell organic molecules or phosphorescent complexes to achieve high electroluminescence efficiencies. In such systems, light emission typically originates from singlet or triplet exciton recombination.
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