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Lajos Pusztai on Muck Rack

Lajos Pusztai

As seen in: Nature, The BMJ, Genome Biology, JAMA Oncology, Medscape, Cell Press, Cell Reports Medicine, The Lancet, HemOnc Today, NewsBreak and
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Articles

Stage-related transcriptional changes in HR-positive/HER2-negative breast cancer

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By Kevin Tran, Kevin Trần, Chunxiao Fu, Hongxia Sun, Lajos Pusztai, Tari A. King, Roberto Salgado, Vicente Valero, W. Fraser Symmans, Eleni Andreopoulou, William S. O. Symmans, Rebekah Gould
| Nature Verified
Abstract It is important to understand how the biology of breast cancer might differ with the burden of disease. Analyzing the expression of cancer-relevant genes with increasing diagnostic stage can provide insight into the changing biology of breast cancer and may also be clinically useful.
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Pan-cancer multi-omic integration of Trop2 reveals biological determinants and translational implications for ADC therapy

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By Giulia Notini, Barbara Galbardi, Giulia Viale, Matteo M. Naldini, Carlo Bosi, Giacomo De Micheli, Luca Licata, Marco Mariani, Marta Piras, Carmen Criscitiello, Marco Barreca, Maurizio Callari, Caterina Zanibelli, Francesca Patanè, Antonella Chiavassa, Jose Perez-Garcia, H. Ali, Javier Cortés, Lajos Pusztai, Luca Gianni, Giampaolo Bianchini, Matteo Dugo
| Nature Verified
Abstract Trop2–directed antibody-drug conjugates (ADCs) show activity across epithelial cancers, yet determinants of target expression in tumors and normal tissues remain poorly defined. We integrated bulk and single-cell transcriptomic profiles from over 20,000 samples across TCGA, GTEx and public atlases to map TACSTD2 expression, regulation and functional correlates in solid malignancies and healthy epithelia.
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Reimagining HER2 therapy: Bridging oncogene addiction and immune modulation

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By Luke Tillman, Lajos Pusztai, Seth A. Wander, Raghav Sundar, Samuel J. Klempner
| Cell Press Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Sheng, T. ∙ Sundar, R. ∙ Srivastava, S. ... Spatial profiling of patient-matched HER2 positive gastric cancer reveals resistance mechanisms to targeted therapy Gut. 2026; 75:733-747 2. Li, Z. ∙ Chen, S. ∙ Feng, W. ... A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy EBioMedicine. 2020; 62, 103074 3. Li, Y. ∙ Zhang, X. ∙ Liu, D. ...
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