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Abstract Obesity, which is often associated with prolonged exposure to an obesogenic diet, substantially alters immunity1,2,3,4,5,6,7, but whether brief dietary changes shape acute inflammatory responses and long-term tissue memory remains unclear. Here we show that transient high-fat diet (HFD) exposure at the onset of acute type 17 skin inflammation exacerbates disease in lean mice to levels comparable to those associated with chronic obesity.
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Abstract T follicular regulatory cells restrain and refine germinal center responses in vivo. B cells rely on T follicular helper cells (TFH) to direct antibody responses within germinal centers, but it is currently unknown how these responses are finely tuned. Although the ability of T follicular regulatory cells (TFR) to suppress B cell responses in vitro has been demonstrated, their role in germinal centers in vivo is less certain. Clement et al.
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