For patients with ulcerative colitis (UC) who have failed multiple lines of therapy, treatment options are limited and outcomes are often poor. A novel investigational approach simultaneously targeting 2 distinct inflammatory pathways with a single fixed-dose co-antibody may offer hope for changing that reality. Phase 2b data from the DUET-UC trial presented at Digestive Disease Week (DDW) 2026 in Chicago, IL, by Maria Abreu, MD, Executive Director of the F.