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Abstract Age is the strongest risk factor for type 2 diabetes, yet their independent contribution to pancreatic islet dysfunction remains unclear. We integrate DNA methylation, transcriptomic, and genotyping data from 144 islet donors. We identify 996 age- and 902 T2D-associated CpGs with minimal overlap, and 251 age- and 310 diabetes CpG target genes, usually distant from the CpG.
Keywords respiratory bacterial infection aging circadian rhythm Rev-erb-α apelin Streptococcus pneumoniae apelin receptor alveolar macrophages Research topics CP: Microbiology CP: Immunology Introduction Immune-function dysregulation has a major impact on age-related diseases, with an elevation in the risk of cancer and cardiovascular, metabolic, and neurodegenerative pathologies.
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