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Bart Staels on Muck Rack

Bart Staels

As seen in: Nature, Gut Journal, Cell Press, Cell Reports, JACC (Journal of the American College of Cardiology), Future Medicine
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Articles

Intestinal FXR deficiency uncouples steatosis protection from liver inflammation and fibrosis in MASH-diet fed mice

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By Margaux Nawrot, Morgane M. Thibaut, Kevin Ory, Véronique Touche, Julie Dubois-Chevalier, Céline Gheeraert, Sandrine CARON, Philippe Lefebvre, Anne Tailleux, Joel Haas Verified, Laure B Bindels, Isabelle A. Leclercq, David Dombrowicz, Bart Staels, Simon Peschard, Emmanuelle Vallez, Emilie Dorchies, Kadiombo Bantubungi, Sophie Lestavel
| Nature Verified
Abstract The Farnesoid X Receptor (FXR), a nuclear bile acid (BA) receptor highly expressed in the liver and intestine, is a potential pharmacological target for Metabolic dysfunction-Associated SteatoHepatitis (MASH). While intestinal FXR inhibition reduces high-fat diet (HFD)-induced hepatic steatosis, its role in MASH progression remains unclear. This study investigates the impact of intestinal FXR-deficiency on MASH development in a diet-induced murine model.
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A functional variant in the porcine APOA2 promoter alters hepatic gene expression via RORα

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By Junhui Liu, Carles Hernández-Banqué, Olga González-Rodríguez, Anna Maria Castello, Anna Merino Castelló, Lourdes Criado-Mesas, Miao Zhang, Bart Staels, Josep M. Folch, Maria Ballester, Alba Chofre
| Nature Verified
Abstract Apolipoprotein A2 is the second most abundant protein in high-density lipoproteins and plays an important role in lipid and glucose metabolism. APOA2 has been identified as a candidate gene influencing fat-related traits in pigs, and genetic variation has been associated with its hepatic expression. The aim of this study was to identify regulatory polymorphisms in the APOA2 promoter and assess their impact on gene expression.
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Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity - Nature Communications

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By Vincent Pascat, Anna Ulrich, Ayşe Demirkan, Zhanna Balkhiyarova, François Pattou, Bart Staels, Marika Kaakinen, Amélie Bonnefond, Patricia B Munroe, Philippe Froguel, Yevheniya Sharhorodska
| Nature Verified
Abstract Type 2 diabetes and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analyse large-scale multiomic data to uncover genetic factors underlying type 2 diabetes and blood pressure comorbidity.
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