Marie Oliver Metzig

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P1 R1: association of TNF to TNFR 10 [1.07, 0.39, 0.91, 0.49] μM−1 min−1 P2 R2: dissociation of TNF:TNFR 10 [−2.00, −2.22, −3.40, −2.20] min−1 P3 R3: degradation of TNF 10 [−1.52, −1.70, −1.62, −1.62] min−1 P4 R4: association of TRADD to complex I 10 [0.11, 0.45, 0.71, 1.19] μM−1 min−1 P5 R5: dissociation of TRADD from complex I 10 [1.22, 1.51, 1.84, 1.30] min−1 P6 R6: association of RIP1-u to complex I 10 [6.30, 5.91, 6.19, 5.94] μM−1 min−1 P7 R7: dissociation of RIP1-u from complex I 10...

The NF-κB differentiator circuit Cytokine concentrations fluctuate in a dynamic manner. Son et al. found that the activity of the NF-κB signaling pathway correlated with the rate of change in the concentrations of the cytokines TNF and IL-1β rather than with absolute cytokine concentrations.