Marielena Sosa

Keywords hippocampus spatial coding navigation plasticity CA1 membrane trafficking population imaging Get full text access Log in, subscribe or purchase for full access. References 1. Diering, G.H. ∙ Huganir, R.L. The AMPA Receptor Code of Synaptic Plasticity Neuron. 2018; 100:314-329 2. Tan, H.L. ∙ Chiu, S.-L. ∙ Zhu, Q. ... GRIP1 regulates synaptic plasticity and learning and memory Proc. Natl. Acad. Sci. USA. 2020; 117:25085-25091 3. Patterson, M.A. ∙ Szatmari, E.M. ∙ Yasuda, R.

Abstract To reinforce rewarding behaviors, events leading up to and following rewards must be remembered. Hippocampal place cell activity spans spatial and non-spatial episodes, but whether hippocampal activity encodes entire sequences of events relative to reward is unknown. Here, to test this possibility, we performed two-photon imaging of hippocampal CA1 as mice navigated virtual environments with changing hidden reward locations.

Abstract Hippocampal place cells fire in sequences that span spatial environments and non-spatial modalities, suggesting that hippocampal activity can anchor to the most behaviorally salient aspects of experience. As reward is a highly salient event, we hypothesized that sequences of hippocampal activity can anchor to rewards. To test this, we performed two-photon imaging of hippocampal CA1 neurons as mice navigated virtual environments with changing hidden reward locations.